Insights on the antitumor effects of kahweol on human breast cancer: Decreased survival and increased production of reactive oxygen species and cytotoxicity

被引：38

作者：

Cardenas, Casimiro ^{[1
,2
,3
]}

Quesada, Ana R. ^{[1
,2
,4
]}

Angel Medina, Miguel ^{[1
,2
,4
]}

机构：

[1] Univ Malaga, Fac Sci, Dept Mol Biol & Biochem, E-29071 Malaga, Spain

[2] IBIMA Biomed Res Inst Malaga, E-29071 Malaga, Spain

[3] Univ Malaga, Res Support Cent Serv SCAI, E-29071 Malaga, Spain

[4] CIBER Enfermedades Raras CIBERER, E-29071 Malaga, Spain

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2014年 / 447卷 / 03期

关键词：

Cancer; Coffee; Kahweol; MDA-MB231 breast cancer cell; ROS; COFFEE CONSUMPTION; DITERPENES CAFESTOL; COMPONENTS KAHWEOL; RISK; LIVER; EXPRESSION; APOPTOSIS; ENZYMES; METAANALYSIS; TRANSFERASE;

D O I：

10.1016/j.bbrc.2014.04.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study aims to identify the modulatory effects of kahweol, an antioxidant diterpene present in coffee beans, on a panel of human tumor cell lines. Kahweol inhibits tumor cell proliferation and clonogenicity and induces apoptosis in several kinds of human tumor cells. In the estrogen receptor-negative MDA-MB231 human breast cancer, the mentioned effects are accompanied by caspases 3/7 and 9 activation and cytochrome c release. On the other hand, kahweol increases the production of reactive oxygen species and their cytotoxicity in human breast cancer cells but not in normal cells. Taken together, our data suggest that kahweol is an antitumor compound with inhibitory effects on tumor cell growth and survival, especially against MDA-MB231 breast cancer cells. (C) 2014 Published by Elsevier Inc.

引用

页码：452 / 458

页数：7

共 29 条

[1] Systems biology for molecular life sciences and its impact in biomedicine [J].

Angel Medina, Miguel .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (06) :1035-1053

[2]

Bengis RO, 1932, J BIOL CHEM, V97, P99

[3] Coffee bean extracts rich and poor in kahweol both give rise to elevation of liver enzymes in healthy volunteers [J].

Boekschoten, Mark V. ;

Schouten, Evert G. ;

Katan, Martijn B. .

NUTRITION JOURNAL, 2004, 3 (1)

[4] Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene [J].

Cardenas, Casimiro ;

Quesada, Ana R. ;

Medina, Miguel A. .

PLOS ONE, 2011, 6 (08)

[5] Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes the Akt pathway [J].

Garcia-Caballero, Melissa ;

Mari-Beffa, Manuel ;

Canedo, Librada ;

Angel Medina, Miguel ;

Quesada, Ana R. .

BIOCHEMICAL PHARMACOLOGY, 2013, 85 (12) :1727-1740

[6]

Giovannucci E, 1998, AM J EPIDEMIOL, V147, P1043, DOI 10.1093/oxfordjournals.aje.a009398

[7] Analysis of the content of the diterpenes cafestol and kahweol in coffee brews [J].

Gross, G ;

Jaccaud, E ;

Huggett, AC .

FOOD AND CHEMICAL TOXICOLOGY, 1997, 35 (06) :547-554

[8] The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

[9] Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein [J].

Higgins, Larry G. ;

Cavin, Christophe ;

Toh, Ken ;

Yamamoto, Masayuki ;

Hayes, John D. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2008, 226 (03) :328-337

[10] Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver -: comparison with phase II xenobiotic metabolism [J].

Huber, WW ;

Scharf, G ;

Nagel, G ;

Prustomersky, S ;

Schulte-Hermann, R ;

Kaina, B .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2003, 522 (1-2) :57-68

← 1 2 3 →