Design of resolving reagents: p-Substituted mandelic acids as resolving reagents for 1-arylalkylamines

被引：58
作者：
Kinbara, K
Sakai, K
Hashimoto, Y
Nohira, H
Saigo, K
机构：
[1] UNIV TOKYO,GRAD SCH ENGN,DEPT CHEM & BIOTECHNOL,BUNKYO KU,TOKYO 113,JAPAN
[2] SAITAMA UNIV,FAC ENGN,DEPT APPL CHEM,URAWA,SAITAMA 338,JAPAN
来源：
TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 06期
基金：
日本学术振兴会;
关键词：
CYCLIC PHOSPHORIC-ACIDS; OPTICAL RESOLUTION; AGENTS;
D O I：
10.1016/0957-4166(96)00175-9
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The resolution of 1-arylakylamines 2-10 by mandelic acid 1 was studied. It was found that a substituent, which elongated the molecular length of the amines, diminished the resolution efficiency. On the basis of these results, (S)-p-methylmandelic acid (S)-11 and (R)-p-methoxymandelic acid (R)-12 were selected as new resolving reagents for the 1-arylalkylamines; these acids were found to have a higher resolving ability than (R)-1. (C) 1996 Elsevier Science Ltd
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页码：1539 / 1542
页数：4
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