Design of resolving reagents: p-Substituted mandelic acids as resolving reagents for 1-arylalkylamines

被引：58

作者：

Kinbara, K

Sakai, K

Hashimoto, Y

Nohira, H

Saigo, K

机构：

[1] UNIV TOKYO,GRAD SCH ENGN,DEPT CHEM & BIOTECHNOL,BUNKYO KU,TOKYO 113,JAPAN

[2] SAITAMA UNIV,FAC ENGN,DEPT APPL CHEM,URAWA,SAITAMA 338,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 06期

基金：

日本学术振兴会;

关键词：

CYCLIC PHOSPHORIC-ACIDS; OPTICAL RESOLUTION; AGENTS;

D O I：

10.1016/0957-4166(96)00175-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The resolution of 1-arylakylamines 2-10 by mandelic acid 1 was studied. It was found that a substituent, which elongated the molecular length of the amines, diminished the resolution efficiency. On the basis of these results, (S)-p-methylmandelic acid (S)-11 and (R)-p-methoxymandelic acid (R)-12 were selected as new resolving reagents for the 1-arylalkylamines; these acids were found to have a higher resolving ability than (R)-1. (C) 1996 Elsevier Science Ltd

引用

页码：1539 / 1542

页数：4

共 9 条

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