What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks

被引：76

作者：

de Paiva, Raphael E. F. ^{[1
]}

Neto, Antonio Marcal ^{[2
]}

Santos, Igor A. ^{[3
]}

Jardim, Ana C. G. ^{[3
]}

Corbi, Pedro P. ^{[4
]}

Bergamini, Fernando R. G. ^{[2
]}

机构：

[1] Univ Sao Paulo, Dept Fundamental Chem, Inst Chem, BR-05508000 Sao Paulo, SP, Brazil

[2] Univ Fed Uberlandia, Inst Chem, Lab Synth Bioinspired Mol, BR-38400902 Uberlandia, MG, Brazil

[3] Univ Fed Uberlandia, Inst Biomed Sci, Lab Virol, BR-38405302 Uberlandia, MG, Brazil

[4] Univ Estadual Campinas, Inst Chem, BR-13083871 Campinas, SP, Brazil

来源：

DALTON TRANSACTIONS | 2020年 / 49卷 / 45期

基金：

巴西圣保罗研究基金会;

关键词：

X-RAY-ABSORPTION; VIRUS TYPE-1 INTEGRASE; ZINC-FINGER DOMAIN; HEPATITIS-C VIRUS; ANTI-HIV; NUCLEOCAPSID PROTEIN; SPECTROSCOPIC CHARACTERIZATION; PLATINUM(II) COMPLEXES; GOLD(III) COMPLEXES; SILVER SULFADIAZINE;

D O I：

10.1039/d0dt02478c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In light of the Covid-19 outbreak, this review brings together historical and current literature efforts towards the development of antiviral metallodrugs. Classical compounds such as CTC-96 and auranofin are discussed in depth, as pillars for future metallodrug development. From the recent literature, both cell-based results and biophysical assays against potential viral biomolecule targets are summarized here. The comprehension of the biomolecular targets and their interactions with coordination compounds are emphasized as fundamental strategies that will foment further development of metal-based antivirals. We also discuss other possible and unexplored methods for unveiling metallodrug interactions with biomolecules related to viral replication and highlight the specific challenges involved in the development of antiviral metallodrugs.

引用

页码：16004 / 16033

页数：30

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