Microvesicles: what is the role in multiple sclerosis?

被引：40

作者：

Carandini, Tiziana ^{[1
]}

Colombo, Federico ^{[1
]}

Finardi, Annamaria ^{[1
]}

Casella, Giacomo ^{[1
]}

Garzetti, Livia ^{[1
]}

Verderio, Claudia ^{[2
,3
]}

Furlan, Roberto ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Inst Expt Neurol, Div Neurosci, I-20132 Milan, Italy

[2] CNR Inst Neurosci, Milan, Italy

[3] IRCCS Humanitas, Rozzano, Italy

来源：

FRONTIERS IN NEUROLOGY | 2015年 / 6卷

关键词：

microvesicles; multiple sclerosis; exosomes; ectosomes; horizontal communication; biomarkers; microglia; INNATE IMMUNE-SYSTEM; ENDOTHELIAL MICROPARTICLES; EXTRACELLULAR VESICLES; MICROGLIA; PLASMA; MACROPHAGES; ACTIVATION; IMPAIRMENT; RECEPTORS; RELEASE;

D O I：

10.3389/fneur.2015.00111

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Microvesicles are a recently described way of cell communication that has been implicated in a number of biological processes, including neuroinflammation. Widely investigated as biomarkers in oncology and neurological disorders, little is known of the role of microvesicles in the pathogenesis of diseases such as multiple sclerosis (MS). Several evidences suggest that pro-inflammatory microglia and infiltrating macrophages release microvesicles that spread inflammatory signals and alter neuronal functions. We review here available information on microvesicles, with a special focus on microglia and macrophage microvesicles, in the pathogenesis of MS, and as potential biomarkers and therapeutic targets.

引用

页数：7

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