The case for a US prospective cohort study of genes and environment

被引:177
作者
Collins, FS [1 ]
机构
[1] NHGRI, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/nature02628
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Information from the Human Genome Project will be vital for defining the genetic and environmental factors that contribute to health and disease. Well-designed case-control studies of people with and without a particular disease are essential for this, but rigorous and unbiased conclusions about the causes of diseases and their population-wide impact will require a representative population to be monitored over time ( a prospective cohort study). The time is right for the United States to consider such a project.
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页码:475 / 477
页数:3
相关论文
共 14 条
[1]   Nature, nurture and human disease [J].
Chakravarti, A ;
Little, P .
NATURE, 2003, 421 (6921) :412-414
[2]   Epidemiological methods for studying genes and environmental factors in complex diseases [J].
Clayton, D ;
McKeigue, PM .
LANCET, 2001, 358 (9290) :1356-1360
[3]   EXPERIMENTAL REQUIREMENTS AND SCIENTIFIC PRINCIPLES IN CASE CONTROL STUDIES [J].
FEINSTEIN, AR .
JOURNAL OF CHRONIC DISEASES, 1985, 38 (02) :127-133
[4]   The International HapMap Project [J].
Gibbs, RA ;
Belmont, JW ;
Hardenbol, P ;
Willis, TD ;
Yu, FL ;
Yang, HM ;
Ch'ang, LY ;
Huang, W ;
Liu, B ;
Shen, Y ;
Tam, PKH ;
Tsui, LC ;
Waye, MMY ;
Wong, JTF ;
Zeng, CQ ;
Zhang, QR ;
Chee, MS ;
Galver, LM ;
Kruglyak, S ;
Murray, SS ;
Oliphant, AR ;
Montpetit, A ;
Hudson, TJ ;
Chagnon, F ;
Ferretti, V ;
Leboeuf, M ;
Phillips, MS ;
Verner, A ;
Kwok, PY ;
Duan, SH ;
Lind, DL ;
Miller, RD ;
Rice, JP ;
Saccone, NL ;
Taillon-Miller, P ;
Xiao, M ;
Nakamura, Y ;
Sekine, A ;
Sorimachi, K ;
Tanaka, T ;
Tanaka, Y ;
Tsunoda, T ;
Yoshino, E ;
Bentley, DR ;
Deloukas, P ;
Hunt, S ;
Powell, D ;
Altshuler, D ;
Gabriel, SB ;
Qiu, RZ .
NATURE, 2003, 426 (6968) :789-796
[5]  
Gordis Leon., 2000, Epidemiology, V2nd
[6]   Inflation of sibling recurrence-risk ratio, due to ascertainment bias and/or overreporting [J].
Guo, SW .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (01) :252-258
[7]   ENVIRONMENT AND DISEASE - ASSOCIATION OR CAUSATION [J].
HILL, AB .
PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1965, 58 (05) :295-+
[8]   Initial sequencing and analysis of the human genome [J].
Lander, ES ;
Int Human Genome Sequencing Consortium ;
Linton, LM ;
Birren, B ;
Nusbaum, C ;
Zody, MC ;
Baldwin, J ;
Devon, K ;
Dewar, K ;
Doyle, M ;
FitzHugh, W ;
Funke, R ;
Gage, D ;
Harris, K ;
Heaford, A ;
Howland, J ;
Kann, L ;
Lehoczky, J ;
LeVine, R ;
McEwan, P ;
McKernan, K ;
Meldrim, J ;
Mesirov, JP ;
Miranda, C ;
Morris, W ;
Naylor, J ;
Raymond, C ;
Rosetti, M ;
Santos, R ;
Sheridan, A ;
Sougnez, C ;
Stange-Thomann, N ;
Stojanovic, N ;
Subramanian, A ;
Wyman, D ;
Rogers, J ;
Sulston, J ;
Ainscough, R ;
Beck, S ;
Bentley, D ;
Burton, J ;
Clee, C ;
Carter, N ;
Coulson, A ;
Deadman, R ;
Deloukas, P ;
Dunham, A ;
Dunham, I ;
Durbin, R ;
French, L .
NATURE, 2001, 409 (6822) :860-921
[9]   Association mapping in structured populations [J].
Pritchard, JK ;
Stephens, M ;
Rosenberg, NA ;
Donnelly, P .
AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (01) :170-181
[10]  
Shi Michael M, 2002, Am J Pharmacogenomics, V2, P197, DOI 10.2165/00129785-200202030-00005