Heritable Human Genome Editing: The Public Engagement Imperative

被引：19

作者：

Adashi, Eli Y. ^{[1
]}

Burgess, Michael M. ^{[2
]}

Burall, Simon ^{[3
]}

Cohen, I. Glenn ^{[4
]}

Fleck, Leonard M. ^{[5
]}

Harris, John ^{[6
]}

Holm, Soren ^{[7
]}

Lafont, Cristina ^{[8
]}

Moreno, Jonathan D. ^{[9
,10
,11
]}

Neblo, Michael A. ^{[12
]}

Niemeyer, Simon J. ^{[13
]}

Rowe, Eugene J. ^{[14
]}

Scheufele, Dietram A. ^{[15
]}

Tetsa, Paul F. ^{[16
]}

Vayena, Effy ^{[17
]}

Watermeyer, Richard P. ^{[18
]}

Fung, Archon ^{[19
]}

机构：

[1] Brown Univ, Dept Med Sci, Providence, RI 02906 USA

[2] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada

[3] Involve, London, England

[4] Harvard Univ, Harvard Law Sch, Cambridge, MA 02138 USA

[5] Michigan State Univ, Dept Philosophy, E Lansing, MI 48824 USA

[6] Kings Coll London, Dept Bioeth, London, England

[7] Univ Manchester, Dept Bioeth, Manchester, Lancs, England

[8] Northwestern Univ, Dept Philosophy, Evanston, IL 60208 USA

[9] Univ Penn, Dept Med Eth & Hlth Policy, Philadelphia, PA 19104 USA

[10] Univ Penn, Dept Hist & Sociol Sci, Philadelphia, PA 19104 USA

[11] Univ Penn, Dept Philosophy, Philadelphia, PA 19104 USA

[12] Ohio State Univ, Dept Polit Sci, Columbus, OH 43210 USA

[13] Univ Canberra, Ctr Deliberat Democracy & Global Governance, Canberra, ACT, Australia

[14] Gene Rowe Evaluat, Norwich, Norfolk, England

[15] Univ Wisconsin, Dept Life Sci Commun, Madison, WI USA

[16] Brown Univ, Dept Polit Sci, Providence, RI 02912 USA

[17] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Zurich, Switzerland

[18] Univ Bristol, Sch Educ, Bristol, Avon, England

[19] Harvard Univ, Kennedy Sch, Cambridge, MA 02138 USA

来源：

CRISPR JOURNAL | 2020年 / 3卷 / 06期

关键词：

SCIENCE; PARTICIPATION;

D O I：

10.1089/crispr.2020.0049

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the view of many, heritable human genome editing (HHGE) harbors the remedial potential of ridding the world of deadly genetic diseases. A Hippocratic obligation, if there ever was one, HHGE is widely viewed as a life-sustaining proposition. The national go/no-go decision regarding the implementation of HHGE, however, must not, in the collective view of the authors, proceed absent thorough public engagement. A comparable call for an "extensive societal dialogue" was recently issued by the International Commission on the Clinical Use of Human Germline Genome Editing. In this communication, the authors lay out the foundational principles undergirding the formation, modification, and evaluation of public opinion. It is against this backdrop that the societal decision to warrant or enjoin the clinical conduct of HHGE will doubtlessly transpire.

引用

页码：434 / 439

页数：6

共 44 条

[1] Heritable Human Genome Editing The International Commission Report [J].