Antioxidant activity and antitumor activity (in vitro) of xyloglucan selenious ester and surfated xyloglucan

被引：38

作者：

Cao, Yu ^{[1
]}

Ikeda, Isao ^{[1
]}

机构：

[1] Univ Fukui, Dept Appl Chem & Biotechnol, Grad Sch Engn, Fukui 9108507, Japan

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2009年 / 45卷 / 03期

基金：

日本学术振兴会;

关键词：

Xyloglucan selenious ester; Sulfated xyloglucan; Antioxidant; Antitumor; Selenition; POLYSACCHARIDES;

D O I：

10.1016/j.ijbiomac.2009.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two kinds of xyloglucan derivatives (xyloglucan selenious ester and sulfated xyloglucan) were prepared and evaluated on antioxidant activity and antitumor activity. Compared with xyloglucan, xyloglucan derivatives have new bioactivity against oxidative damage and tumor. Furthermore, xyloglucan selenious ester is more potent than sulfated xyloglucan at antioxidant activity and antitumor activity in vitro. The current data suggest for the first time that selenition of xyloglucan significantly increases its bioactivity and the chemical modification of polysaccharide may allow the preparation of derivatives with new properties and a variety of applications. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：231 / 235

页数：5

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