Fungicidal activity of natural and synthetic sesquiterpene lactone analogs

被引：178

作者：

Wedge, DE

Galindo, JCG

Macías, FA

机构：

[1] ARS, USDA, Nat Prod Utilizat Res Unit, University, MS 38677 USA

[2] Univ Cadiz, Fac Ciencias, Dept Quim Organ, Cadiz 11520, Spain

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 07期

关键词：

fungicides; dehydrozaluzanin C; zaluzanin C; dehydrocostuslactone; costunolide; 5; alpha-hydroxydehydrocostuslactone; sesquiterpene lactones; Colletotrichum acutatum; Colletotrichum fragariae; Colletotrichum gloeosporioides; Fusarium oxysporum; Botrytis cinerea; Phomopsis sp;

D O I：

10.1016/S0031-9422(00)00008-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fungicidal activity of 36 natural and synthetic sesquiterpene lactones with guaianolide, trans, trans-germacranolide, cis, cis-germacranolide, melampolide, and eudesmanolide carbon skeletons was evaluated against the phytopathogenic fungi Colletotrichum acutatum, C. fragariae, C. gloeosporioides, Fusarium oxysporum. Botrytis cinerea, and Phomopsis sp. Dose response data for the active compounds dehydrozaluzanin C. dehydrocostuslactone, 5 alpha-hydroxydehydrocostuslacone, costunolide, and zaluzanin C are presented. A new 96-well microbioassay procedure for fast and easy evaluation of antifungal activity was used to compare these compounds with commercial fungicide standards. Some structure-activity conclusions are also presented. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：747 / 757

页数：11

共 34 条

[1]

[Anonymous], 1989, FUNGI PLANT PLANT PR

[2] Structure - Cytotoxicity relationships of some helenanolide-type sesquiterpene lactones [J].