Fabrication of All Glass Bifurcation Microfluidic Chip for Blood Plasma Separation

被引：17

作者：

Jang, Hyungjun ^{[1
]}

Haq, Muhammad Refatul ^{[1
]}

Ju, Jonghyun ^{[1
]}

Kim, Youngkyu ^{[1
]}

Kim, Seok-min ^{[1
]}

Lim, Jiseok ^{[2
]}

机构：

[1] Chung Ang Univ, Sch Mech Engn, Seoul 06974, South Korea

[2] Yeungnam Univ, Sch Mech Engn, Gyongsan 38541, Gyeongsangbuk D, South Korea

来源：

MICROMACHINES | 2017年 / 8卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

glass molding; amorphous carbon mold; microfluidics; blood plasma separation; bifurcation microfluidic chip; CELL-SEPARATION; EXTRACTION; DEVICE; LASER; ACOUSTOPHORESIS; MICROCHANNEL; MICROSCALE; PARTICLE; LENS;

D O I：

10.3390/mi8030067

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An all-glass bifurcation microfluidic chip for blood plasma separation was fabricated by a cost-effective glass molding process using an amorphous carbon (AC) mold, which in turn was fabricated by the carbonization of a replicated furan precursor. To compensate for the shrinkage during AC mold fabrication, an enlarged photoresist pattern master was designed, and an AC mold with a dimensional error of 2.9% was achieved; the dimensional error of the master pattern was 1.6%. In the glass molding process, a glass microchannel plate with negligible shape errors (similar to 1.5%) compared to AC mold was replicated. Finally, an all-glass bifurcation microfluidic chip was realized by micro drilling and thermal fusion bonding processes. A separation efficiency of 74% was obtained using the fabricated all-glass bifurcation microfluidic chip.

引用

页数：11

共 38 条

[1] Fabrication of Glass-based Microfluidic Devices with Photoresist as Mask [J].