Asymmetric Allylic Alkylation of -Ketoesters with Allylic Alcohols by a Nickel/Diphosphine Catalyst

被引：113

作者：

Kita, Yusuke ^{[1
]}

Kavthe, Rahul D. ^{[1
]}

Oda, Hiroaki ^{[1
]}

Mashima, Kazushi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn Sci, Dept Chem, Toyonaka, Osaka 5608531, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 03期

关键词：

alkylation; allylic compounds; asymmetric catalysis; enantioselectivity; nickel; ALPHA-ALLYLATION; COUPLING REACTIONS; NICKEL-COMPLEXES; DUAL CATALYSIS; PALLADIUM; SUBSTITUTION; ACTIVATION; LIGANDS; KETONES; ALDEHYDES;

D O I：

10.1002/anie.201508757

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric allylic alkylation of -ketoesters with allylic alcohols catalyzed by [Ni(cod)(2)]/(S)-H-8-BINAP was found to be a superior synthetic protocol for constructing quaternary chiral centers at the -position of -ketoesters. The reaction proceeded in high yield and with high enantioselectivity using various -ketoesters and allylic alcohols, without any additional activators. The versatility of this methodology for accessing useful and enantioenriched products was demonstrated.

引用

页码：1098 / 1101

页数：4

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