Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats

被引:73
作者
Suleyman, Halis [1 ]
Cadirci, Elif [1 ]
Albayrak, Abdulmecit [1 ]
Polat, Beyzagul [2 ]
Halici, Zekai [1 ]
Koc, Feride [3 ]
Hacimuftuoglu, Ahmet [1 ]
Bayir, Yasin [4 ]
机构
[1] Ataturk Univ, Fac Med, Dept Pharmacol, TR-25240 Erzurum, Turkey
[2] Ataturk Univ, Fac Pharm, Dept Toxicol, TR-25240 Erzurum, Turkey
[3] Ataturk Univ, Fac Vet Med, Dept Pharmacol & Toxicol, TR-25240 Erzurum, Turkey
[4] Ataturk Univ, Fac Pharm, Dept Biochem, TR-25240 Erzurum, Turkey
关键词
Antioxidant enzymes; Indomethacin; Rat; Tianeptine; Ulcer; GASTRIC-MUCOSAL INJURY; OXIDATIVE STRESS; LIPID-PEROXIDATION; DUODENAL-ULCER; NITRIC-OXIDE; ETHANOL; DAMAGE; ACID; INHIBITION; SEROTONIN;
D O I
10.1016/j.cbi.2009.03.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Clinical studies have shown that anxiolytic and antidepressant drug therapy benefits patients with ulcers. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. This study investigated the antiulcer activities of tianeptine, trazodone, and venlafaxine on indomethacin-induced ulcers in rats: and evaluated tianeptine's effects on oxidant and antioxidant parameters in rat stomach tissue. The results show that trazodone and venlafaxine did not prevent indomethacin-induced ulcers. Tianeptine, however, decreased indomethacin-induced ulcers significantly at all doses used (6,12, and 25 mg/kg). Famotidine, an H-2 receptor blocker, showed the highest antiulcer activity. Tianeptine significantly prevented the decrease in glutathione (GSH) content that occurred in the indomethacin-only group's damaged stomach tissues. All doses of tianeptine, but especially the 25 mg/kg dose, significantly decreased catalase (CAT) activity in stomach tissue, compared to the control. All doses of tianeptine eliminated the decrease in superoxide dismutase (SOD) activity in the stomach tissue of rats given indomethacin. Although all doses of tianeptine significantly decreased the malondialdehyde (MDA) content, all doses of tianeptine, except 6 mg/kg, decreased myeloperoxidase (MPO) activities significantly compared to the control. Our results indicate that activating enzymatic and non-enzymatic antioxidant mechanisms and inhibiting some toxic oxidant mechanisms play a role in tianeptine's antiulcer effect mechanism. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:318 / 324
页数:7
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