Immune-based identification of cancer patients at high risk of progression

被引：12
作者：
Vano, Yann-Alexandre [1 ,2 ,3 ,4 ]
Petitprez, Florent [1 ,2 ,3 ,5 ]
Giraldo, Nicolas A. [6 ]
Fridman, Wolf H. [1 ,2 ,3 ]
Sautes-Fridman, Catherine [1 ,2 ,3 ]
机构：
[1] INSERM, Cordeliers Res Ctr, Team Canc Immune Control & Escape, UMR S 1138, F-75006 Paris, France
[2] Univ Paris Descartes Paris 5, Sorbonne Paris Cite, Ctr Rech Cordeliers, UMR S 1138, F-75006 Paris, France
[3] Sorbonne Univ, Univ UPMC Paris 6, UMR S1138, F-75006 Paris, France
[4] Univ Descartes Paris 5, Georges Pompidou European Hosp, Dept Med Oncol, Paris, France
[5] Ligue Natl Contre Canc, Programme Cartes Identite Tumeurs, Common immune features TME high risk patients pr, Paris, France
[6] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2018年 / 51卷
关键词：
TERTIARY LYMPHOID STRUCTURES; RENAL-CELL CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; T-CELLS; LUNG ADENOCARCINOMA; PROGNOSTIC VALUE; EXPRESSION; MICROENVIRONMENT; CONTEXTURE; SURVIVAL;
D O I：
10.1016/j.coi.2018.03.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tumors are highly heterogeneous structures where malignant cells interact with a large variety of cell populations, including a clinically-relevant immune component. We review and compare the most recent methods designed to analyze and quantify the composition of immune and stromal microenvironment of tumors and discuss their use in identification of patients for high risk of progression. If the impact of the various immune components on patient's relapse share common rules in most malignancies, clear cell renal cell tumors behave differently with regards to immunity. We focus on this specific pathology to show how the tumor interacts with the host's immune system and how this intricate relationship shapes the clinical outcome.
引用
收藏
页码：97 / 102
页数：6
相关论文
共 47 条
[1]   Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression [J].
Becht, Etienne ;
Giraldo, Nicolas A. ;
Lacroix, Laetitia ;
Buttard, Benedicte ;
Elarouci, Nabila ;
Petitprez, Florent ;
Selves, Janick ;
Laurent-Puig, Pierre ;
Sautes-Fridman, Catherine ;
Fridman, Wolf H. ;
de Reynies, Aurelien .
GENOME BIOLOGY, 2016, 17
[2]   Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers [J].
Becht, Etienne ;
Giraldo, Nicolas A. ;
Germain, Claire ;
de Reynies, Aurelien ;
Laurent-Puig, Pierre ;
Zucman-Rossi, Jessica ;
Dieu-Nosjean, Marie-Caroline ;
Sautes-Fridman, Catherine ;
Fridman, Wolf H. .
TUMOR IMMUNOLOGY, 2016, 130 :95-190
[3]   Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC) [J].
Becht, Etienne ;
Giraldo, Nicolas A. ;
Beuselinck, Benoit ;
Job, Sylvie ;
Marisa, Laetitia ;
Vano, Yann ;
Oudard, Stephane ;
Zucman-Rossi, Jessica ;
Laurent-Puig, Pierre ;
Sautes-Fridman, Catherine ;
de Reynies, Aurelien ;
Fridman, Wolf Herman .
ONCOIMMUNOLOGY, 2015, 4 (12)
[4]   Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting [J].
Beuselinck, Benoit ;
Job, Sylvie ;
Becht, Etienne ;
Karadimou, Alexandra ;
Verkarre, Virginie ;
Couchy, Gabrielle ;
Giraldo, Nicolas ;
Rioux-Leclercq, Nathalie ;
Molinie, Vincent ;
Sibony, Mathilde ;
Elaidi, Reza ;
Teghom, Corinne ;
Patard, Jean-Jacques ;
Mejean, Arnaud ;
Fridman, Wolf Herman ;
Sautes-Fridman, Catherine ;
de Reynies, Aurelien ;
Oudard, Stephane ;
Zucman-Rossi, Jessica .
CLINICAL CANCER RESEARCH, 2015, 21 (06) :1329-1339
[5]   Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer [J].
Bindea, Gabriela ;
Mlecnik, Bernhard ;
Tosolini, Marie ;
Kirilovsky, Amos ;
Waldner, Maximilian ;
Obenauf, Anna C. ;
Angell, Helen ;
Fredriksen, Tessa ;
Lafontaine, Lucie ;
Berger, Anne ;
Bruneval, Patrick ;
Fridman, Wolf Herman ;
Becker, Christoph ;
Pages, Franck ;
Speicher, Michael R. ;
Trajanoski, Zlatko ;
Galon, Jerome .
IMMUNITY, 2013, 39 (04) :782-795
[6]   The Role of Tumor-Infiltrating Lymphocytes in Development, Progression, and Prognosis of Non-Small Cell Lung Cancer [J].
Bremnes, Roy M. ;
Busund, Lill-Tove ;
Kilvaer, Thomas L. ;
Andersen, Sigve ;
Richardsen, Elin ;
Paulsen, Erna Elise ;
Hald, Sigurd ;
Khanehkenari, Mehrdad Rakaee ;
Cooper, Wendy A. ;
Kao, Steven C. ;
Donnem, Tom .
JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (06) :789-800
[7]   Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer [J].
Carstens, Julienne L. ;
de Sampaio, Pedro Correa ;
Yang, Dalu ;
Barua, Souptik ;
Wang, Huamin ;
Rao, Arvind ;
Allison, James P. ;
LeBleu, Valerie S. ;
Kalluri, Raghu .
NATURE COMMUNICATIONS, 2017, 8
[8]   Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade [J].
Charoentong, Pornpimol ;
Finotello, Francesca ;
Angelova, Mihaela ;
Mayer, Clemens ;
Efremova, Mirjana ;
Rieder, Dietmar ;
Hackl, Hubert ;
Trajanoski, Zlatko .
CELL REPORTS, 2017, 18 (01) :248-262
[9]   Heavy Metal Enlightens Tumor Immunity [J].
Chen, Jonathan H. ;
Pelka, Karin ;
Hacohen, Nir .
CELL, 2017, 169 (04) :567-569
[10]   An Immune Atlas of Clear Cell Renal Cell Carcinoma [J].
Chevrier, Stephane ;
Levine, Jacob Harrison ;
Zanotelli, Vito Riccardo Tomaso ;
Silina, Karina ;
Schulz, Daniel ;
Bacac, Marina ;
Ries, Carola Hermine ;
Ailles, Laurie ;
Jewett, Michael Alexander Spencer ;
Moch, Holger ;
van den Broek, Maries ;
Beisel, Christian ;
Stadler, Michael Beda ;
Gedye, Craig ;
Reis, Bernhard ;
Pe'er, Dana ;
Bodenmiller, Bernd .
CELL, 2017, 169 (04) :736-749
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