Subnanometer-Resolution Frequency Modulation Atomic Force Microscopy in Liquid for Biological Applications

被引：17
作者：
Fukuma, Takeshi [1 ,2 ]
机构：
[1] Kanazawa Univ, Frontier Sci Org, Kakuma, Kanazawa 9201192, Japan
[2] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan
来源：
JAPANESE JOURNAL OF APPLIED PHYSICS | 2009年 / 48卷 / 08期
基金：
日本科学技术振兴机构;
关键词：
SILICON (111)-(7X7) SURFACE; TIO2(110) SURFACE; AQUEOUS-SOLUTIONS; LIPID-BILAYERS; MEMBRANES; PHASE; SPECTROSCOPY; FIBRILS; BINDING; LAYERS;
D O I：
10.1143/JJAP.48.08JA01
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
The spatial resolution and force sensitivity of frequency modulation atomic force microscopy (FM-AFM) in liquid have been dramatically improved in the last a few years. It is now possible to image individual atoms and molecules at a solid/liquid interface with a subnanometer-scale resolution and a piconewton-order loading force. This capability enabled the direct visualization of hydration layers and mobile ions on a lipid bilayer and beta-strands constituting an amyloid fibril. These striking results highlighted the significant potential of FM-AFM in biological research, Here, I summarize the technological innovation that brought about this progress and review biological applications of FM-AFM in liquid. (C) 2009 The Japan Society of Applied Physics
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页数：7
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