Most Good, Least Harm: Isoform-Specific Targeting of ROCK in Pulmonary Fibrosis

被引：0
作者：
Zhou, Yong [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
来源：
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2018年 / 58卷 / 04期
基金：
美国国家卫生研究院;
关键词：
RHO-KINASE-II;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：421 / 422
页数：2
相关论文
共 14 条
  • [1] Rho kinase inhibitors: a patent review (2014-2016)
    Defert, Olivier
    Boland, Sandro
    [J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2017, 27 (04) : 507 - 515
  • [2] Matrix Stiffness-Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction
    Huang, Xiangwei
    Yang, Naiheng
    Fiore, Vincent F.
    Barker, Thomas H.
    Sun, Yi
    Morris, Stephan W.
    Ding, Qiang
    Thannickal, Victor J.
    Zhou, Yong
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2012, 47 (03) : 340 - 348
  • [3] The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis
    Knipe, Rachel S.
    Probst, Clemens K.
    Lagares, David
    Franklin, Alicia
    Spinney, Jillian J.
    Brazee, Patricia L.
    Grasberger, Paula
    Zhang, Linlin
    Black, Katharine E.
    Sakai, Norihiko
    Shea, Barry S.
    Liao, James K.
    Medoff, Benjamin D.
    Tager, Andrew M.
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2018, 58 (04) : 471 - 481
  • [4] The Rho Kinases: Critical Mediators of Multiple Profibrotic Processes and Rational Targets for New Therapies for Pulmonary Fibrosis
    Knipe, Rachel S.
    Tager, Andrew M.
    Liao, James K.
    [J]. PHARMACOLOGICAL REVIEWS, 2015, 67 (01) : 103 - 117
  • [5] Rho-associated kinase(ROCK)function is essential for cell cycle progression, senescence and tumorigenesis
    Kuemper, Sandra
    Mardakheh, Faraz K.
    McCarthy, Afshan
    Yeo, Maggie
    Stamp, Gordon W.
    Paul, Angela
    Worboys, Jonathan
    Sadok, Amine
    Jorgensen, Claus
    Guichard, Sabrina
    Marshall, Christopher J.
    [J]. ELIFE, 2016, 5
  • [6] Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation
    Lock, Frances E.
    Hotchin, Neil A.
    [J]. PLOS ONE, 2009, 4 (12):
  • [7] Rho kinases in cardiovascular physiology and pathophysiology
    Loirand, G
    Guérin, P
    Pacaud, P
    [J]. CIRCULATION RESEARCH, 2006, 98 (03) : 322 - 334
  • [8] ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice
    Nakagawa, O
    Fujisawa, K
    Ishizaki, T
    Saito, Y
    Nakao, K
    Narumiya, S
    [J]. FEBS LETTERS, 1996, 392 (02) : 189 - 193
  • [9] Applications for ROCK kinase inhibiton
    Olson, Michael F.
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2008, 20 (02) : 242 - 248
  • [10] Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment
    Shi, Jianjian
    Wu, Xiangbing
    Surma, Michelle
    Vemula, Sasidhar
    Zhang, Lumin
    Yang, Yu
    Kapur, Reuben
    Wei, Lei
    [J]. CELL DEATH & DISEASE, 2013, 4 : e483 - e483
12