Experimental murine models of brainstem gliomas

被引：3
作者：
Ni, Shuting [1 ]
Chen, Rujing [1 ,2 ]
Hu, Kaili [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Murad Res Ctr Modernized Chinese Med, Shanghai 201203, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Pharm, Shanghai 200025, Peoples R China
来源：
DRUG DISCOVERY TODAY | 2022年 / 27卷 / 05期
关键词：
Experimental murine model; Brainstem glioma; Diffuse intrinsic pontine glioma; INTRINSIC PONTINE GLIOMA; CONVECTION-ENHANCED DELIVERY; PEDIATRIC HIGH-GRADE; MOUSE MODEL; DIFFUSE; CELLS; GLIOBLASTOMA; INHIBITION; CHILDREN; TUMORS;
D O I：
10.1016/j.drudis.2021.12.016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
As an intractable central nervous system (CNS) tumor, brainstem glioma (BG) is one of the leading causes of pediatric death by brain tumors. Owing to the risk of surgical resection and the little improvement in survival time after radiotherapy and chemotherapy, there is an urgent need to find reliable model systems to better understand the regional pathogenesis of the brainstem and improve treatment strategies. In this review, we outline the evolution of BG murine models, and discuss both their advantages and limitations in drug discovery.
引用
收藏
页码：1218 / 1235
页数：18
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