Lysophosphatidylinositols, from Cell Membrane Constituents to GPR55 Ligands

被引：74

作者：

Alhouayek, Mireille ^{[1
]}

Masquelier, Julien ^{[1
]}

Muccioli, Giulio G. ^{[1
]}

机构：

[1] Catholic Univ Louvain, Louvain Drug Res Inst, Bioanal & Pharmacol Bioact Lipids Res Grp, B-1200 Brussels, Belgium

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2018年 / 39卷 / 06期

关键词：

CANNABINOID RECEPTOR GPR55; L-ALPHA-LYSOPHOSPHATIDYLINOSITOL; ACTIVATED PROTEIN-KINASE; LARGE HEAD GROUPS; AGONIST LYSOPHOSPHATIDYLINOSITOL; POTENTIAL ROLE; INTRACELLULAR CALCIUM; POSSIBLE INVOLVEMENT; SIGNALING PATHWAYS; INSULIN-SECRETION;

D O I：

10.1016/j.tips.2018.02.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lysophosphatidylinositols (LPIs) are membrane constituents that alter the properties of said membranes. However, recent data showing that the once orphan receptor, GPR55, can act as a receptor for LPIs has sparked a renewed interest in LPIs as bioactive lipids. As evidence supporting the importance of LPIs and/or GPR55 is continuously accumulating and because LPI levels are altered in a number of pathologies such as obesity and cancer, the coming years should bring new, exciting discoveries to this field. In this review, we discuss the recent work on LPIs and on their molecular target, the GPR55 receptor. First, we summarize the metabolism of LPIs before outlining the cellular pathways activated by GPR55. Then, we review the actions of LPIs and GPR55 that could have potential pharmacological or therapeutic applications in several pathophysiological settings, such as cancer, obesity, pain, and inflammation.

引用

收藏

页码：586 / 604

页数：19

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