FRZB up-regulated in hepatocellular carcinoma bone metastasis

被引：1
作者：
Huang, Jia [1 ]
Hu, Wenhao [2 ]
Lin, Xiangjin [3 ]
Wang, Xuanwei [3 ]
Jin, Ketao [4 ]
机构：
[1] Ningbo Univ, Sch Med, Yinzhou Hosp, Dept Canc Chemotherapy & Radiotherapy, Ningbo 315040, Zhejiang, Peoples R China
[2] Ningbo Univ, Sch Med, Yinzhou Hosp, Dept Canc Chemotherapy & Radiotherapy, Ningbo 315040, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Orthoped, Hangzhou 310003, Zhejiang, Peoples R China
[4] Zhejiang Univ, Shaoxing Hosp, Shaoxing Peoples Hosp, Dept Gastrointestinal Surg, Shaoxing 312000, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Hepatocellular carcinoma; bone metastasis; frizzled-related protein (FRZB); HEPATITIS-B-VIRUS; CLINICAL-FEATURES; PROTEIN; INVOLVEMENT; ANTAGONIST; EXPRESSION; CIRRHOSIS; GROWTH; CELLS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The clinical relevance of frizzled-related protein (FRZB) in hepatocellular carcinoma (HCC) bone metastasis remains uncertain. The aim of this study was to assess the clinical relationship of FRZB in patients with HCC bone metastasis after surgical resection. FRZB expression was evaluated by immunohistochemistry in formalinfixed paraffin embedded (FFPE) HCC and paired bone metastasis tissues from 13 patients that underwent surgical resection. The clinical characteristics of 13 HCC patients with synchronous or metachronous bone metastasis received surgery were retrospectively reviewed. We found that FRZB was positive in 9 HCC tissues (69.2%) and in 11 paired bone metastatic tissues (84.6%) among these 13 paired samples. The expression of FRZB in the bone metastases was noticeably higher than that in the paired HCC tissues. The expression of FRZB was up-regulated in 10 (76.9%) paired bone metastases tissues. FRZB expression was up-regulated in HCC bone metastasis tissue, which suggested that FRZB might play a key role in the HCC bone metastasis.
引用
收藏
页码：13353 / 13359
页数：7
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