Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats

被引：48

作者：

Jung, Chang Hwa

Zhou, Song

Ding, Guo Xun

Kim, Ji Hye

Hong, Myung Hee

Shin, Yong-Cheol

Kim, Gyung Jun

Ko, Seong-Gyu ^{[1
]}

机构：

[1] Kyung Hee Univ, Lab Clin Biol & Pharmacogenom, Coll Oriental Med, Seoul 130701, South Korea

[2] Kyung Hee Univ, Inst Oriental Med, Seoul 130701, South Korea

[3] Kyungwon Univ, Dept Ophthalmol & Otorhinolaryngol, Coll Oriental Med, Songnam 461701, Kyunggi Do, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 10期

关键词：

herb extracts; Rhus verniciflua; blood glucose; thiobarbituric acid reactive substances; diabetic rats;

D O I：

10.1271/bbb.60238

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P < 0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by Rhus verniciflua (50 mg/kg) supplementation in diabetic rats.

引用

页码：2556 / 2559

页数：4

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