Natural compounds against cytotoxic drug-induced cardiotoxicity: A review on the involvement of PI3K/Akt signaling pathway

被引：31

作者：

Yarmohammadi, Fatemeh ^{[1
,2
]}

Hayes, A. Wallace ^{[3
,4
]}

Karimi, Gholamreza ^{[2
,5
]}

机构：

[1] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran

[3] Univ S Florida, Coll Publ Hlth, Tampa, FL 33620 USA

[4] Michigan State Univ, Inst Integrat Toxicol, E Lansing, MI 48824 USA

[5] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2021年 / 35卷 / 03期

关键词：

Akt; cardiotoxicity; cytotoxic drugs; natural compounds; PI3K; DOXORUBICIN-INDUCED CARDIOTOXICITY; NF-KAPPA-B; INDUCED CARDIOMYOCYTE APOPTOSIS; C-26; COLON-CARCINOMA; SALVIANOLIC ACID B; FERULIC ACID; ASTRAGALOSIDE IV; OXIDATIVE STRESS; PHENOLIC-COMPOUNDS; INDUCED INJURY;

D O I：

10.1002/jbt.22683

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiotoxicity is a critical concern in the use of several cytotoxic drugs. Induction of apoptosis, inflammation, and autophagy following dysregulation of the PI3K/Akt signaling pathway contributes to the cardiac damage induced by these drugs. Several natural compounds (NCs), including ferulic acid, gingerol, salvianolic acid B, paeonol, apigenin, calycosin, rutin, neferine, higenamine, vincristine, micheliolide, astragaloside IV, and astragalus polysaccharide, have been reported to suppress cytotoxic drug-induced cardiac injury. This article reviews these NCs that have been reported to have a protective effect against cytotoxic drug-induced cardiotoxicity through regulation of the PI3K/Akt signaling pathway.

引用

页数：11

共 119 条

[1] Rutin, an antioxidant flavonoid, induces glutathione and glutathione peroxidase activities to protect against ethanol effects in cadmium-induced oxidative stress in the testis of adult rats [J].