Design, synthesis, and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents

被引：126

作者：

Tandon, Vishnu K. ^{[1
]}

Yadav, Dharmendra B.

Maurya, Hardesh K.

Chaturvedi, Ashok K.

Shukla, Praveen K.

机构：

[1] Univ Lucknow, Dept Chem, Lucknow 226007, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Fermentat Technol, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 17期

关键词：

antifungal; antibacterial; quinoxaline-5; 10-diones; heterocyclic quinones; 1,4-naphthoquinone derivatives;

D O I：

10.1016/j.bmc.2006.04.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of (S)-N-(3-chloro-1,4-naphthoquinon-2-yl)-alpha-amino acid ethyl esters 3 and 1,2,3-trisubstituted-1,4dihydrobenzo[g]quinoxaline-5,10-diones 6-23 were synthesized and evaluated for antifungal and antibacterial activities. The structure-activity relationship of these compounds was studied and the results show that the compounds 3a and 3b exhibited in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, and Sporothrix schenckii whereas compounds 12 and 22 showed in vitro antibacterial activity against Klebsiella pneumoniae and Escherichia coli. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6120 / 6126

页数：7

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