Advances in Therapeutics for Neurodegenerative Tauopathies: Moving toward the Specific Targeting of the Most Toxic Tau Species

被引：66

作者：

Gerson, Julia E. ^{[1
]}

Castillo-Carranza, Diana L. ^{[1
]}

Kayed, Rakez ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Neurol, George & Cynthia Mitchell Ctr Alzheimers Dis Res, Galveston, TX 77555 USA

来源：

ACS CHEMICAL NEUROSCIENCE | 2014年 / 5卷 / 09期

关键词：

Oligomers; immunotherapy; molecular chaperones; small molecules; PAIRED HELICAL FILAMENTS; NUCLEATED CONFORMATIONAL CONVERSION; MICROTUBULE-STABILIZING AGENT; HEAT-SHOCK PROTEINS; ALZHEIMERS-DISEASE; MOUSE MODEL; AMYLOID-BETA; IN-VITRO; A-BETA; METHYLENE-BLUE;

D O I：

10.1021/cn500143n

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurodegenerative disease is one of the greatest health concerns today and with no effective treatment in sight, it is crucial that researchers find a safe and successful therapeutic. While neurofibrillary tangles are considered the primary tauopathy hallmark, more evidence continues to come to light to suggest that soluble, intermediate tau aggregates tau oligomers-are the most toxic species in disease. These intermediate tau species may also be responsible for the spread of pathology, suggesting that oligomeric tau may be the best therapeutic target. Here, we summarize results for the modulation of tau by molecular chaperones, small molecules and aggregation inhibitors, post-translational modifications, immunotherapy, other techniques, and future directions.

引用

页码：752 / 769

页数：18

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