Local mechanical and structural properties of healthy and diseased human ascending aorta tissue

被引:178
作者
Choudhury, Nusrat [1 ]
Bouchot, Olivier [2 ]
Rouleau, Leonie [1 ,2 ]
Tremblay, Dominique [1 ,2 ]
Cartier, Raymond [2 ]
Butany, Jagdish [3 ]
Mongrain, Rosaire [2 ,4 ]
Leask, Richard L. [1 ,2 ]
机构
[1] McGill Univ, Dept Chem Engn, Montreal, PQ H3A 2B2, Canada
[2] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada
[3] Toronto Gen Hosp, Univ Hlth Network, Toronto, ON, Canada
[4] McGill Univ, Dept Mech Engn, Montreal, PQ H3A 2B2, Canada
基金
加拿大自然科学与工程研究理事会; 加拿大健康研究院; 加拿大创新基金会;
关键词
Aorta; Bicuspid; Mechanics; Hemodynamics; Elastic modulus; BIOMECHANICAL BEHAVIOR; MEDIAL DEGENERATION; WALL STRESS; ANEURYSM; VALVE; DISTENSIBILITY; ELASTICITY; ARTERIES;
D O I
10.1016/j.carpath.2008.01.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: This study investigates the mechanics and histology of healthy and dilated human ascending aortas (AA). The regional variation in mechanical response and tissue structure were compared. Methods: Rings of human AA From healthy (n=5), dilated tricuspid aortic valve (TAV, n=5), and dilated bicuspid aortic valve (BAV, n=6) patients were mechanically tested. Each aortic ring was sectioned into quadrants-anterior, posterior, medial (inner Curvature) and lateral (Outer curvature). Low- and high-stress elastic moduli Were calculated from the equibiaxial stress strain curve to determine the local mechanical properties. Histological analysis was used to quantify the percent composition of elastin. collagen, and smooth muscle cells. Results: BAV tissue was thinnest and contained the far est percent composition of collagen. Both TAV and BAV tissue had significantly less elastin than healthy tissue. At low strain in the circumferential direction, TAV tissue was oil average the least stiff. The elastic modulus was dependent oil quadrant and tissue type but not direction (isotropic). Generally the lateral quadrant tissue was the stiffest and the medial quadrant the least stiff. There were no apparent local variations in the tissue histology. Conclusions: Local variations in tissue thickness and mechanical properties were evident in all samples analyzed and may be linked to the type of aortic valve present. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:83 / 91
页数:9
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