Effects of insulin-like growth factor on nitrogen balance during hypoxic exposure

被引:12
作者
Iioka, Y [1 ]
Tatsumi, K [1 ]
Sugito, K [1 ]
Moriya, T [1 ]
Kuriyama, T [1 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Respirol B2, Chuo Ku, Chiba 2608670, Japan
关键词
catabolism; hypoxia; insulin growth factor-1; nitrogen balance; total parenteral nutrition;
D O I
10.1183/09031936.02.00234302
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Acute exacerbations of chronic obstructive pulmonary disease (COPD) accompanied with hypoxaemia may induce not protein catabolism and hypoxaemia could be an important trigger of a systemic catabolic response. The aim of this study was to examine the anabolic effects of recombinant human insulin-like growth factor-I (IGF-I) in rats exposed to hypoxia. Although acute hypoxia is usually accompanied with a decrease in dietary intake, the usual nitrogen intake was maintained in this study. Sprague-Dawley rats were maintained by continuous infusion of solution for total parenteral nutrition for 6 days. The animals were then randomly assigned to a normoxic (N) or a hypoxic (H) group. During the last 3 days of the experiment N and H rats were randomised to receive either IGF-I or vehicle. Exposure to hypoxia caused a decrease in body-weight gain accompanied by a negative nitrogen balance, which was mainly due to increased urinary nitrogen excretion. No effect of recombinant human IGF-I treatment on body weight was observed during exposure to hypoxia, although nitrogen balance normalised. The co-infusion of recombinant human insulin-like growth factor-1 and total parenteral nutrition has a significant net anabolic effect, as demonstrated by nitrogen retention and reduction in urine protein excretion observed in rats. Insulin-like growth factor-1 may help to ameliorate the protein catabolism observed tinder hypoxic conditions.
引用
收藏
页码:293 / 299
页数:7
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