DNA-guided hepatitis B treatment: Viral load is insufficient with few exceptions

被引：1
作者：
Jain, Pankaj [1 ]
机构：
[1] Apollo Modi Hosp, Kota 324010, Rajasthan, India
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 12期
关键词：
DNA; Hepatitis B; Viral load; NATURAL-HISTORY; VIRUS-INFECTION; HBV-DNA; EXACERBATION; MANAGEMENT;
D O I：
10.3748/wjg.15.1530
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In DNA-guided hepatitis B treatment, viral load is insufficient, and requires other viral markers for treatment of hepatitis B patients as in patients with acute exacerbation of chronic hepatitis B, end-stage renal disease on dialysis, human immunodeficiency virus co-infected patients. There are exceptions to this rule: a residual level hepatitis B virus (HBV) DNA at 24 wk predicts beneficial outcome and reduced resistance at 1 year. The genotypic viral resistance to antiviral agents and occult HBV infection can be determined by HBV-DNA levels. (C) 2009 The WJG Press and Baishideng. All rights reserved.
引用
收藏
页码：1530 / 1531
页数：2
相关论文
共 17 条
  • [1] DNA-guided hepatitis B treatment, viral load is essential, but not sufficient
    Barcena Marugan, Rafael
    Garcia Garzon, Silvia
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (04) : 423 - 430
  • [2] Quantification of intrahepatic hepatitis B virus (HBV) DNA in patients with chronic HBV infection
    Cacciola, I
    Pollicino, T
    Squadrito, G
    Cerenzia, G
    Villari, D
    De Franchis, R
    Santantonio, T
    Brancatelli, S
    Colucci, G
    Raimondo, G
    [J]. HEPATOLOGY, 2000, 31 (02) : 507 - 512
  • [3] Time-dependent events in natural history of occult hepatitis B virus infection: the importance of population-based long-term follow-up study with repeated measurements
    Chen, CJ
    [J]. JOURNAL OF HEPATOLOGY, 2005, 42 (04) : 438 - 440
  • [4] Occult hepatitis B virus infection: A hidden menace?
    Conjeevaram, H
    Lok, AS
    [J]. HEPATOLOGY, 2001, 34 (01) : 204 - 206
  • [5] DETECTION OF SERUM HBV-DNA BY POLYMERASE CHAIN-REACTION (PCR) IN PATIENTS BEFORE REACTIVATION OF CHRONIC HEPATITIS-B
    GAYNO, S
    MARCELLIN, P
    LORIOT, MA
    MARTINOTPEIGNOUX, M
    LEVY, P
    ERLINGER, S
    BENHAMOU, JP
    [J]. JOURNAL OF HEPATOLOGY, 1992, 14 (2-3) : 357 - 360
  • [6] Report of an international workshop: Roadmap for management of patients receiving oral therapy for chronic hepatitis B
    Keeffe, Emmet B.
    Zeuzem, Stefan
    Koff, Raymond S.
    Dieterich, Douglas T.
    Esteban-Mur, Rafael
    Gane, Edward J.
    Jacobson, Ira M.
    Lim, Seng G.
    Naoumov, Nikolai
    Marcellin, Patrick
    Piratvisuth, Teerha
    Zoulim, Fabien
    [J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (08) : 890 - 897
  • [7] Viral hepatitis in HIV infection
    Koziel, Margaret James
    Peters, Marion G.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (14) : 1445 - 1454
  • [8] Differentiating acute hepatitis B from the first episode of symptomatic exacerbation of chronic hepatitis B
    Kumar, M
    Jain, S
    Sharma, BC
    Sarin, SK
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2006, 51 (03) : 594 - 599
  • [9] Locarnini S, 2004, ANTIVIR THER, V9, P679
  • [10] Chronic hepatitis B
    Lok, Anna S. F.
    McMahon, Brian J.
    [J]. HEPATOLOGY, 2007, 45 (02) : 507 - 539
12