Presenile dementia syndromes: an update on taxonomy and diagnosis

被引:53
作者
Greicius, MD
Geschwind, MD
Miller, BL
机构
[1] Univ Calif San Francisco, Memory & Aging Ctr, Sch Med, Dept Neurol, San Francisco, CA 94117 USA
[2] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
关键词
D O I
10.1136/jnnp.72.6.691
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The four major degenerative dementias that often begin in presenescence: are reviewed. These are Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, and Creutzfeldt-Jakob disease. Their epidemiological, genetic, and clinical features are reviewed, and controversies in taxonomy arising from recent discoveries described. Particular attention is given to the pathological role of protein aggregation, which appears to be a factor in each disease.
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页码:691 / 700
页数:10
相关论文
共 177 条
  • [1] Alzheimers Assoc, 1998, NEUROBIOL AGING, V19, P109
  • [2] DISTRIBUTION OF ALZHEIMER-TYPE PATHOLOGICAL-CHANGES IN NONDEMENTED ELDERLY INDIVIDUALS MATCHES THE PATTERN IN ALZHEIMERS-DISEASE
    ARRIAGADA, PV
    MARZLOFF, K
    HYMAN, BT
    [J]. NEUROLOGY, 1992, 42 (09) : 1681 - 1688
  • [3] MRI volumetric study of dementia with Lewy bodies - A comparison with AD and vascular dementia
    Barber, R
    Ballard, C
    McKeith, IG
    Gholkar, A
    O'Brien, JT
    [J]. NEUROLOGY, 2000, 54 (06) : 1304 - 1309
  • [4] Transmissible spongiform encephalopathies in humans
    Belay, ED
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, 1999, 53 : 283 - 314
  • [5] Early destruction of the extracellular matrix around parvalbumin-immunoreactive interneurons in Creutzfeldt-Jakob disease
    Belichenko, PV
    Miklossy, J
    Belser, B
    Budka, H
    Celio, MR
    [J]. NEUROBIOLOGY OF DISEASE, 1999, 6 (04) : 269 - 279
  • [6] POSTERIOR CORTICAL ATROPHY
    BENSON, DF
    DAVIS, RJ
    SNYDER, BD
    [J]. ARCHIVES OF NEUROLOGY, 1988, 45 (07) : 789 - 793
  • [7] Berrios GermanE., 1996, HIST MENTAL SYMPTOMS
  • [8] RELIABILITY AND VALIDITY OF NINCDS-ADRDA CRITERIA FOR ALZHEIMERS-DISEASE - THE NATIONAL-INSTITUTE-OF-MENTAL-HEALTH GENETIC INITIATIVE
    BLACKER, D
    ALBERT, MS
    BASSETT, SS
    GO, RCP
    HARRELL, LE
    FOLSTEIN, MF
    [J]. ARCHIVES OF NEUROLOGY, 1994, 51 (12) : 1198 - 1204
  • [9] Alpha-2 macroglobulin is genetically associated with Alzheimer disease
    Blacker, D
    Wilcox, MA
    Laird, NM
    Rodes, L
    Horvath, SM
    Go, RCP
    Perry, R
    Watson, B
    Bassett, SS
    McInnis, MG
    Albert, MS
    Hyman, BT
    Tanzi, RE
    [J]. NATURE GENETICS, 1998, 19 (04) : 357 - 360
  • [10] ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS
    BLESSED, G
    TOMLINSON, BE
    ROTH, M
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) : 797 - +