Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery

被引：24

作者：

Gartenberg, Marc R. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 09期

关键词：

Chromatin; DNA double-strand break; DNA repair; Mps3p; Rad52; 3C; DOUBLE-STRAND BREAK; DOMAIN PROTEIN MPS3; SACCHAROMYCES-CEREVISIAE; YEAST TELOMERASE; RECOMBINATION; ENVELOPE; MAINTENANCE; PATHWAYS; SPINDLE; COMPLEX;

D O I：

10.1101/gad.1805309

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Persistent DNA double-strand breaks and telomeres represent genomic hazards, as they can instigate inappropriate repair reactions. Two recent papers by Oza and colleagues (pp. 912-917) and Schober and colleagues (pp. 928-938) show that both types of DNA ends are sequestered from bulk DNA by Mps3, a SUN domain protein that spans the inner nuclear membrane. Anchorage maintains telomere integrity and steers double-strand breaks toward specialized repair pathways. This work defines the nuclear periphery as a subcompartment where dangerous DNA elements can be handled with care.

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收藏

页码：1027 / 1031

页数：5

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