Working memory impairments in first-episode psychosis and chronic schizophrenia

被引：37

作者：

Zanello, Adriano ^{[1
]}

Curtis, Logos ^{[1
]}

Ba, Maryse Badan ^{[1
]}

Merlo, Marco C. G. ^{[1
]}

机构：

[1] Univ Hosp Geneva, Div Adult Psychiat, Dept Psychiat, CH-1202 Geneva, Switzerland

来源：

PSYCHIATRY RESEARCH | 2009年 / 165卷 / 1-2期

关键词：

Neurocognition; Working memory; First-episode schizophrenia; Chronic schizophrenia; N-back task; PREMORBID ADJUSTMENT; DYSFUNCTION; DEFICITS; ONSET; INFORMATION; DIMENSIONS; EFFICIENCY; COGNITION; DURATION; BACK;

D O I：

10.1016/j.psychres.2007.10.006

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Working memory (WM) impairments are core cognitive deficits in patients with schizophrenia linked to prefrontal cortical dysfunctions. Determining the differences between early phases of illness allows a better understanding of its course and constitutes an important guide for treatment. The present cross-sectional study examined differences of working memory functions between 33 first-episode and 29 chronic schizophrenic patients, as well as 64 healthy controls. On the basis of a two-back visual-verbal computerized working memory task, reaction time was slower and accuracy was worse in both patient groups than in controls. Test variables, however, were not significantly different between the patient groups, suggesting stability of the deficits over time. Effect size accuracy variables nevertheless showed larger deficits in chronic patients. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：10 / 18

页数：9

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