SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients

被引：53

作者：

Montagna, M. T. ^{[1
]}

Lovero, G. ^{[1
]}

Coretti, C. ^{[1
]}

Martinelli, D. ^{[2
]}

Delia, M. ^{[3
]}

De Giglio, O. ^{[1
]}

Caira, M. ^{[4
]}

Puntillo, F. ^{[5
]}

D'Antonio, D. ^{[6
]}

Venditti, M. ^{[7
]}

Sambri, V. ^{[8
]}

Di Bernardo, F. ^{[9
]}

Barbui, A. ^{[10
]}

Lo Cascio, G. ^{[11
]}

Concia, E. ^{[12
]}

Mikulska, M. ^{[13
]}

Viscoli, C. ^{[13
]}

Maximova, N. ^{[14
]}

Candoni, A. ^{[15
]}

Oliveri, S. ^{[16
]}

Lombardi, G. ^{[17
]}

Pitzurra, L. ^{[18
]}

Sanguinetti, M. ^{[19
]}

Masciari, R. ^{[20
]}

Santantonio, T. ^{[21
]}

Andreoni, S. ^{[22
]}

Barchiesi, F. ^{[23
]}

Pecile, P. ^{[24
]}

Farina, C. ^{[25
]}

Viale, P. ^{[26
]}

Specchia, G. ^{[3
]}

Caggiano, G. ^{[1
]}

Pagano, L. ^{[4
]}

机构：

[1] Univ Bari, Hyg Sect, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy

[2] Univ Foggia, Hyg Sect, Dept Med & Surg Sci, I-71100 Foggia, Italy

[3] Univ Bari, Hematol Sect, Dept Emergency & Organ Transplantat, I-70124 Bari, Italy

[4] Univ Cattolica Sacro Cuore, Inst Hematol, I-00168 Rome, Italy

[5] Univ Bari, Dept Emergency & Organ Transplantat, Anesthesia & Intens Care Unit, I-70124 Bari, Italy

[6] Hosp Spirito Santo, I-65100 Pescara, Italy

[7] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

[8] Univ Hosp St Orsola, Clin Microbiol Unit, I-40138 Bologna, Italy

[9] ARNAS Gen Hosp Civ, Lab Clin Microbiol, I-90127 Palermo, Italy

[10] Hosp Citta Salute & Sci, SC Microbiol & Virol, I-10126 Turin, Italy

[11] Univ Verona, Dept Pathol & Diagnost, Microbiol & Virol Unit, I-37134 Verona, Italy

[12] Univ Verona, Dept Pathol, I-37134 Verona, Italy

[13] Univ Hosp IRCCS San Martino, Dept Hlth Sci, Div Infect Dis, I-16132 Genoa, Italy

[14] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34137 Trieste, Italy

[15] Univ Udine, Div Hematol & Bone Marrow Transplantat, I-33100 Udine, Italy

[16] Univ Catania, Dept Biomed Sci, I-95124 Catania, Italy

[17] Hosp Niguarda Ca Granda, Microbiol & Virol Lab, I-20162 Milan, Italy

[18] Univ Perugia, Dept Expt Med, I-06123 Perugia, Italy

[19] Univ Cattolica Sacro Cuore, Inst Microbiol, Dept Expt Med, I-00168 Rome, Italy

[20] AO Pugliese Ciaccio, Microbiol & Virol Lab, I-88100 Catanzaro, Italy

[21] Univ Foggia, Clin Infect Dis, I-71100 Foggia, Italy

[22] AOU Maggiore Carita, Microbiol & Virol Lab, I-28100 Novara, Italy

[23] Univ Marche, Dept Biomed Sci & Publ Hlth, Clin Infect Dis, I-60121 Ancona, Italy

[24] Careggi Hosp, Microbiol Lab, I-50134 Florence, Italy

[25] Hosp San Carlo Borromeo, Inst Microbiol, I-20147 Milan, Italy

[26] Univ Bologna, Dept Med & Surg Sci, Infect Dis Unit, I-40126 Bologna, Italy

来源：

INFECTION | 2014年 / 42卷 / 01期

关键词：

Filamentous fungal infections; Italian survey; Hematological patients; Non-hematological patients; INTENSIVE-CARE-UNIT; BRONCHOALVEOLAR LAVAGE FLUID; INVASIVE ASPERGILLOSIS; RISK-FACTORS; EPIDEMIOLOGIC TRENDS; GALACTOMANNAN; DIAGNOSIS; SERUM; MULTICENTER; FLUCONAZOLE;

D O I：

10.1007/s15010-013-0539-3

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We compared the risk factors, the diagnostic tools and the outcome of filamentous fungal infections (FFIs) in hematological patients (HAEs) and non-hematological patients (non-HAEs). Prospective surveillance (2009-2011) of proven and probable FFIs was implemented in 23 Italian hospitals. Out of 232 FFIs, 113 occurred in HAEs and 119 in non-HAEs. The most frequent infection was invasive aspergillosis (76.1 % for HAEs, 56.3 % for non-HAEs), and the localization was principally pulmonary (83.2 % for HAEs, 74.8 % for non-HAEs). Neutropenia was a risk factor for 89.4 % HAEs; the main underlying condition was corticosteroid treatment (52.9 %) for non-HAEs. The distribution of proven and probable FFIs was different in the two groups: proven FFIs occurred more frequently in non-HAEs, whereas probable FFIs were correlated with the HAEs. The sensitivity of the galactomannan assay was higher for HAEs than for non-HAEs (95.3 vs. 48.1 %). The overall mortality rate was 44.2 % among the HAEs and 35.3 % among the non-HAEs. The etiology influenced the patient outcomes: mucormycosis was associated with a high mortality rate (57.1 % for HAEs, 77.8 % for non-HAEs). The epidemiological and clinical data for FFIs were not identical in the HAEs and non-HAEs. The differences should be considered to improve the management of FFIs according to the patients' setting.

引用

页码：141 / 151

页数：11

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