Curcumol Suppresses Triple-negative Breast Cancer Metastasis by Attenuating Anoikis Resistance via Inhibition of Skp2-mediated Transcriptional Addiction

被引：23
作者：
Li, Chung-Liang [1 ,2 ]
Huang, Chia-Wei [3 ]
Ko, Chin-Ju [1 ,2 ]
Fang, Shao-Yu [3 ]
Fu Ou-Yang [1 ,2 ]
Pan, Mei-Ren [3 ,4 ]
Luo, Chi-Wen [1 ,2 ,4 ]
Hou, Ming-Feng [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Kaohsiung Med Univ Hosp, Dept Surg, 100 Tzyou 1st Rd, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ Hosp, Dept Surg, Div Breast Surg, Kaohsiung, Taiwan
[3] Kaohsiung Med Univ, Grad Inst Clin Med, 100 Shin Chuan 1st Rd, Kaohsiung 807, Taiwan
[4] Kaohsiung Med Univ, Drug Dev & Value Creat Res Ctr, Kaohsiung, Taiwan
[5] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
[6] Kaohsiung Med Univ, Cohort Res Ctr, Kaohsiung, Taiwan
来源：
ANTICANCER RESEARCH | 2020年 / 40卷 / 10期
关键词：
Triple-negative breast cancer; curcumol; anoikis; Skp2; SKP2; AKT; GROWTH; APOPTOSIS; CELLS;
D O I：
10.21873/anticanres.14565
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Triple-negative breast cancer (TNBC) is a unique subtype that lacks expression of several conventional biomarkers and has a higher incidence of lymph node invasion and distal metastasis among all breast cancers. Anoikis resistance is the fundamental reason behind tumor cells' survival without their attachment to the extracellular matrix and metastasis to distal organs. Therefore, finding novel anti-cancer drugs that can suppress anoikis resistance in cancer cells is critical for patients with TNBC. Materials and Methods: Curcumol, a natural compound, was used to assess whether it can inhibit the anoikis resistance and affects cell mortality and motility of IV2-1 TNBC cells. Results: Curcumol suppressed anoikis resistance and inhibited TNBC cell survival in suspension. Additionally, these anti-cancer effects induced by curcumol could be related to the YAP1/Skp2 molecular pathway. Conclusion: Curcumol is an effective Skp2-targeted therapy that attenuates anoikis resistance and metastasis in TNBC cells.
引用
收藏
页码：5529 / 5538
页数：10
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