IMMP2L: a mitochondrial protease suppressing cellular senescence

被引：6
作者：
Sica, Valentina [1 ,2 ,3 ,4 ]
Kroemer, Guido [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Ctr Rech Cordeliers, INSERM, U1138, Equipe Labelisee Ligue Natl Canc 11, F-75006 Paris, France
[2] Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France
[3] Univ Paris 06, F-75006 Paris, France
[4] GRCC, Metabol & Cell Biol Platforms, F-94805 Villejuif, France
[5] Hop Europeen Georges Pompidou, Pole Biol, F-75015 Paris, France
[6] Karolinska Inst, Dept Womens & Childrens Hlth, Karolinska Univ Hosp, S-17176 Stockholm, Sweden
来源：
CELL RESEARCH | 2018年 / 28卷 / 06期
关键词：
LIFE-SPAN; AIF;
D O I：
10.1038/s41422-018-0051-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular senescence contributes to organismal aging and tumor suppression. A recent paper by Yuan et al. published in Cell Research now unveils that switching off a mitochondrial protease can simultaneously suppress phospholipid biosynthesis and lethal signaling for senescence induction.
引用
收藏
页码：607 / 608
页数：2
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