S100A12 is not expressed in rodents: Transgenic mouse model is needed

被引：4

作者：

Bagheri, Vahid ^{[1
]}

机构：

[1] Rafsanjan Univ Med Sci, Res Inst Basic Med Sci, Immunol Infect Dis Res Ctr, Rafsanjan, Iran

来源：

MOLECULAR IMMUNOLOGY | 2022年 / 152卷

关键词：

S100A12; Transgenic; Mice; S100A8; S100A9; INFLAMMATION;

D O I：

10.1016/j.molimm.2022.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

I read with interest the article authored by Zhang et al. (2020) who examined the role of S100A12 in the pathogenesis of sepsis-induced ARDS (acute respiratory distress syndrome). They used wild-type (WT) mice to measure the expression of S100A12 after induction of sepsis in mice. Based on the fact that S100A12 is not present in the murine genome, the interpretation of the findings could be misleading. Therefore, I discuss the use of S100A12 transgenic mouse models to examine S100A12 expression in mice.

引用

页码：35 / 35

页数：1

共 6 条

[1] Comment on "Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis" [J].