Synthesis of C-14-labelled satigrel

被引：0

作者：

Tanaka, S ^{[1
]}

Yamagishi, Y ^{[1
]}

Kusano, K ^{[1
]}

Yoshimura, T ^{[1
]}

机构：

[1] EISAI & CO LTD,TSUKUBA RES LABS,TSUKUBA,IBARAKI 30026,JAPAN

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1996年 / 38卷 / 05期

关键词：

anti-platelet aggregation agent; C-14-labelled satigrel; 4-cyano-5-(4'-methoxy[ring-U-C-14]phenyl)-5-(4''-methoxyphenyl)-4-pentenoic acid; synthesis;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

C-14-Labelled satigrel, or 4-cyano-5-(4'-methoxy [ring-U-C-14] phenyl)-5-(4 ''-methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4, 4'-dimethoxy [ring-U-C-14] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioactivity and radiochemical purity, as determined by radio-HPLC analysis, were 10.3 MBq(277.2 mu Ci)/mg and 98.8%, respectively.

引用

页码：435 / 440

页数：6

共 50 条

[21] Synthesis of Deuterium-Labelled Salicylcarnosine [J].

Shevchenko, V. P. ;

Nagaev, I. Yu. ;

Kulikova, O. I. ;

Myasoedov, N. F. .

DOKLADY CHEMISTRY, 2023, 511 (01) :181-185

[22] Synthesis of deuterium-labelled trantinterol [J].

Wen, Hongliang ;

Pan, Li ;

Zhang, Yingdan ;

Ma, Jiacheng ;

Qin, Liqiong ;

Cheng, Maosheng .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2010, 53 (13-14) :779-781

[23] Synthesis of Tritium and Deuterium Labelled Agmatine [J].

Hong Xia HE Zhi Bing ZHENG Lan Fu CHEN Zhan Bin ZHANG Chun HU Song LI Shenyang Pharmaceutical University Shenyang Beijing Institute of Pharmacology and Toxicology Beijing Beijing Normal University Beijing .

ChineseChemicalLetters, 2006, (05) :587-590

[24] Synthesis of deuterium-labelled chlorhexidine [J].

Moser, M. ;

Hudlicky, T. ;

Sadeghi, S. ;

Sternin, E. .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2007, 50 (7-8) :671-674

[25] Synthesis of Deuterium-Labelled Salicylcarnosine [J].

V. P. Shevchenko ;

I. Yu. Nagaev ;

O. I. Kulikova ;

N. F. Myasoedov .

Doklady Chemistry, 2023, 511 :181-185

[26] Synthesis of 14C-labeled E4010 [J].

Watanabe, N ;

Tokumura, T ;

Nakamura, T .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2001, 44 (12) :843-847

[27] Synthesis of multi-labeled [14C]Aripiprazole [J].

Bonacorsi, SJ ;

Waller, SC ;

Rinehart, JK .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2006, 49 (01) :1-9

[28] A short and simple synthesis of branched mannooligosaccharides with [1-13C]-labelled terminal mannose units [J].

Ivlev, EA ;

Backinowsky, LV ;

Abronina, PI ;

Kononov, LO ;

Kochetkov, NK .

POLISH JOURNAL OF CHEMISTRY, 2005, 79 (02) :275-286

[29] Studies of the total synthesis of epothilone B and D: A facile synthesis of C7-C14 and C15-C21 fragments [J].

Zhang, HS ;

Zhong, CF ;

Bao, XP .

CHINESE CHEMICAL LETTERS, 2003, 14 (02) :115-117

[30] Studies of the Total Synthesis of Epothilone B and D: A Facile Synthesis of C7-C14 and C15-C21 Fragments [J].

He Sheng ZHANG Chuan Fu ZHONG Xiao Ping BAO Department of Chemistry Hubei University Wuhan .

Chinese Chemical Letters, 2003, (02) :115-117

← 1 2 3 4 5 →