Synthesis of C-14-labelled satigrel

被引：0

作者：

Tanaka, S ^{[1
]}

Yamagishi, Y ^{[1
]}

Kusano, K ^{[1
]}

Yoshimura, T ^{[1
]}

机构：

[1] EISAI & CO LTD,TSUKUBA RES LABS,TSUKUBA,IBARAKI 30026,JAPAN

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1996年 / 38卷 / 05期

关键词：

anti-platelet aggregation agent; C-14-labelled satigrel; 4-cyano-5-(4'-methoxy[ring-U-C-14]phenyl)-5-(4''-methoxyphenyl)-4-pentenoic acid; synthesis;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

C-14-Labelled satigrel, or 4-cyano-5-(4'-methoxy [ring-U-C-14] phenyl)-5-(4 ''-methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4, 4'-dimethoxy [ring-U-C-14] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioactivity and radiochemical purity, as determined by radio-HPLC analysis, were 10.3 MBq(277.2 mu Ci)/mg and 98.8%, respectively.

引用

页码：435 / 440

页数：6

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