Poloxamer-Stabilized Topical Miconazole Nitrate-Loaded Microemulsion: Formulation Design and Characterization

被引：4
|
作者：
Ofokansi, Kenneth Chibuzor [1 ]
Kenechukwu, Franklin Chimaobi [1 ]
Isah, A. B. [2 ]
机构：
[1] Univ Nigeria, Fac Pharmaceut Sci, Dept Pharmaceut, Drug Delivery Res Unit, Nsukka 410001, Enugu State, Nigeria
[2] Ahmadu Bello Univ, Dept Pharmaceut & Pharmaceut Microbiol, Zaria, Nigeria
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2013年 / 34卷 / 11期
关键词：
Globule size; miconazole nitrate; microemulsion; thermodynamic stability; IN-VITRO; DELIVERY; DRUG; BIOAVAILABILITY; RELEASE; ENHANCEMENT; PERMEATION; CARRIERS; ACID;
D O I：
10.1080/01932691.2012.752713
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Miconazole nitrate-loaded microemulsion based on Tween 80 and propylene glycol, castor oil and water with and without Poloxamer 407 was prepared and characterized with respect to drug content, stability, antifungal, and physicochemical properties and ex vivo drug release using a modified Franz diffusion apparatus. Results obtained revealed homogeneous and stable microemulsions with excellent physicochemical properties, permeation coefficients and fluxes, and increased in vitro antifungal activity (approximate to 1.2 times) against clinically isolated Candida albicans when compared to a commercial topical miconazole (Fungusol) solution. Poloxamer-stabilized microemulsion could offer a better and more reliable approach of delivering miconazole than both the unstabilized and Fungusol formulations.
引用
收藏
页码：1563 / 1574
页数：12
相关论文
共 50 条
  • [41] Solidified Reverse Micellar Solution-Based Lipid Microparticles of Miconazole Nitrate: Formulation Design, Biopharmaceutical Characterization, and Dissolution Studies
    Uronnachi, Emmanuel
    Attama, Anthony
    Umeyor, Chukwuebuka
    Nwakile, Calistus
    Kenechukwu, Franklin
    Reginald-Opara, Joy
    JOURNAL OF PHARMACEUTICAL INNOVATION, 2022, 17 (02) : 399 - 413
  • [42] Solidified Reverse Micellar Solution-Based Lipid Microparticles of Miconazole Nitrate: Formulation Design, Biopharmaceutical Characterization, and Dissolution Studies
    Emmanuel Uronnachi
    Anthony Attama
    Chukwuebuka Umeyor
    Calistus Nwakile
    Franklin Kenechukwu
    Joy Reginald-Opara
    Journal of Pharmaceutical Innovation, 2022, 17 : 399 - 413
  • [43] Chrysin-Loaded Microemulsion: Formulation Design, Evaluation and Antihyperalgesic Activity in Mice
    Ramalho, izola Morais de Medeiros
    Bezerra, Gabriela Suassuna
    Ostrosky, Elissa Arantes
    Ferrari, Marcio
    Oliveira, Veronica da Silva
    Wanderley Neto, Alcides de Oliveira
    Quintans, Jullyana de Souza Siqueira
    Passos, Fabiolla Rocha Santos
    Heimfarth, Luana
    Quintans-Junior, Lucindo Jose
    Damasceno, Bolivar Ponciano Goulart de Lima
    Converti, Attilio
    de Lima, adley Antonini Neves
    APPLIED SCIENCES-BASEL, 2022, 12 (01):
  • [44] Preparation, Characterization, and In Vitro Permeation Study of Terbinafine HCl in Poloxamer 407-Based Thermogelling Formulation for Topical Application
    Lusiana
    Mueller-Goymann, Christel C.
    AAPS PHARMSCITECH, 2011, 12 (02): : 496 - 506
  • [45] Exploiting response surface D-optimal design study for preparation and optimization of spanlastics loaded with miconazole nitrate as a model antifungal drug for topical application
    Mervat Shafik Ibrahim
    Omar A. Elkady
    Mai A. Amer
    Shereen H. Noshi
    Journal of Pharmaceutical Innovation, 2023, 18 : 2402 - 2418
  • [46] Formulation of Miconazole-Loaded Chitosan-Carbopol Vesicular Gel: Optimization to In Vitro Characterization, Irritation, and Antifungal Assessment
    Imam, Syed Sarim
    Gilani, Sadaf Jamal
    Zafar, Ameeduzzafar
    Bin Jumah, May Nasser
    Alshehri, Sultan
    PHARMACEUTICS, 2023, 15 (02)
  • [47] Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation
    Verma, Poonam
    Pathak, Kamla
    NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2012, 8 (04) : 489 - 496
  • [48] Formulation of acyclovir-loaded solid lipid nanoparticles: design, optimization, and in-vitro characterization
    El-Gizawy, Sanaa A.
    El-Maghraby, Gamal M.
    Hedaya, Asmaa A.
    PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2019, 24 (10) : 1287 - 1298
  • [49] Formulation and Characterization of Febuxostat Loaded Nanostructured Lipid Carriers (NLCs)-Gel for Topical Treatment of Gout
    Sharma, Navni
    Kumar, Sandeep
    Joshi, Garima
    Choudhary, Deepak
    RECENT PATENTS ON NANOTECHNOLOGY, 2022, 16 (03) : 250 - 258
  • [50] Full factorial design, physicochemical characterization, ex vivo investigation, and biological assessment of glutathione-loaded solid lipid nanoparticles for topical application
    Liu, Mengyang
    Sharma, Manisha
    Lu, Guo-Liang
    Zhang, Zhiwen
    Yin, Naibo
    Wen, Jingyuan
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, 630
12345