Poloxamer-Stabilized Topical Miconazole Nitrate-Loaded Microemulsion: Formulation Design and Characterization

被引：4
|
作者：
Ofokansi, Kenneth Chibuzor [1 ]
Kenechukwu, Franklin Chimaobi [1 ]
Isah, A. B. [2 ]
机构：
[1] Univ Nigeria, Fac Pharmaceut Sci, Dept Pharmaceut, Drug Delivery Res Unit, Nsukka 410001, Enugu State, Nigeria
[2] Ahmadu Bello Univ, Dept Pharmaceut & Pharmaceut Microbiol, Zaria, Nigeria
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2013年 / 34卷 / 11期
关键词：
Globule size; miconazole nitrate; microemulsion; thermodynamic stability; IN-VITRO; DELIVERY; DRUG; BIOAVAILABILITY; RELEASE; ENHANCEMENT; PERMEATION; CARRIERS; ACID;
D O I：
10.1080/01932691.2012.752713
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Miconazole nitrate-loaded microemulsion based on Tween 80 and propylene glycol, castor oil and water with and without Poloxamer 407 was prepared and characterized with respect to drug content, stability, antifungal, and physicochemical properties and ex vivo drug release using a modified Franz diffusion apparatus. Results obtained revealed homogeneous and stable microemulsions with excellent physicochemical properties, permeation coefficients and fluxes, and increased in vitro antifungal activity (approximate to 1.2 times) against clinically isolated Candida albicans when compared to a commercial topical miconazole (Fungusol) solution. Poloxamer-stabilized microemulsion could offer a better and more reliable approach of delivering miconazole than both the unstabilized and Fungusol formulations.
引用
收藏
页码：1563 / 1574
页数：12
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