SERRS coded nanoparticles for biomolecular labelling with wavelength-tunable discrimination

被引:15
作者
McKenzie, Fiona [1 ]
Ingram, Andrew [1 ]
Stokes, Robert [1 ]
Graham, Duncan [1 ]
机构
[1] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland
基金
英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词
SURFACE-ENHANCED RAMAN; SINGLE-MOLECULE DETECTION; COLLOIDAL SILVER; SCATTERING; DNA; GOLD; DYES; ACID; OLIGONUCLEOTIDES; CYTOTOXICITY;
D O I
10.1039/b813821d
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The preparation and use of tri-functional linkers for surface complexation to both gold and silver nanoparticles is reported. These molecules confer excellent stability towards nanoparticles ensuring particle monodispersity in biological buffers, and also incorporate dyes to allow use of the functionalised nanoparticles as SERRS reporters. Biomolecule conjugation and quantitation has been illustrated using Alexafluor 680 labelled streptavidin. Variation of the chromophore has been introduced, which allows for exquisite control of the SERRS by manipulation of laser wavelength. This demonstrates the potential of SERRS functionalised nanoparticles for multiple, simultaneous monitoring of excitation events, an area of research where the capability of molecular fluorophores and quantum dots is limited.
引用
收藏
页码:549 / 556
页数:8
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