DNA-catalyzed hydrolysis of DNA phosphodiesters

被引：10

作者：

Fekry, Mostafa I. ^{[1
]}

Gates, Kent S.

机构：

[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 10期

关键词：

WATER; BOND;

D O I：

10.1038/nchembio.224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrolysis of the phosphodiester linkages in DNA is a notoriously difficult reaction. Deoxyribozymes that use Zn(2+) and Mn(2+) ions to accelerate this reaction by a factor of one hundred million (or more) have been identified and characterized.

引用

页码：710 / 711

页数：3

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