Efficient Amination of Activated and Non-Activated C(sp3)-H Bonds with a Simple Iron-Phenanthroline Catalyst

被引：30

作者：

Jarrige, Lucie ^{[1
]}

Zhou, Zijun ^{[1
]}

Hemming, Marcel ^{[1
]}

Meggers, Eric ^{[1
]}

机构：

[1] Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35043 Marburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 12期

关键词：

catalysis; C-H amination; imidazolidin-2-ones; iron; nitrene; C-H AMINATION; NITRENE TRANSFER-REACTIONS; ORGANIC-SYNTHESIS; METAL; FUNCTIONALIZATION; CHALLENGES; COMPLEXES; ANALOGS; AZIDES; SCOPE;

D O I：

10.1002/anie.202013687

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A readily available catalyst consisting of iron dichloride in combination with 1,10-phenanthroline catalyzes the ring-closing C-H amination of N-benzoyloxyurea to form imidazolidin-2-ones in high yields. The C-H amination reaction is very general and applicable to benzylic, allylic, propargylic, and completely non-activated aliphatic C(sp(3))-H bonds, and it also works for C(sp(2))-H bonds. The surprisingly simple method can be performed under open flask conditions.

引用

页码：6314 / 6319

页数：6

共 71 条

[1] Recent applications of C-H functionalization in complex natural product synthesis [J].