Acute restraint increases NADPH-diaphorase staining in distinct subregions of the rat dorsal raphe nucleus: Implications for raphe serotonergic and nitrergic transmission

被引：17

作者：

Okere, Chuma O. ^{[1
]}

Waterhouse, Barry D. ^{[1
]}

机构：

[1] Drexel Univ, Coll Med, Dept Neurobiol & Anat, Philadelphia, PA 19129 USA

来源：

BRAIN RESEARCH | 2006年 / 1119卷

关键词：

dorsal raphe nucleus; NADPH-diaphorase; nitric oxide; nitric oxide synthase; restraint stress;

D O I：

10.1016/j.brainres.2006.08.058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The brainstem dorsal raphe nucleus (DRN) maintains a rough topographic cell ordering with respect to biological function. This study examined the influence of acute restraint on nitric oxide (NO) synthase (NOS) neurons in distinct DRN subregions. NADPH diaphorase staining (NOS index) intensity was higher in the DRN dorsomedial, ventromedial and lateral wings subregions of restrained vs. control rats. The mean number of cells was not significantly different between both groups of animals. The restrained-induced NADPH-diaphorase activity was significantly higher in the rostral ventromedial and caudal lateral wings than the corresponding caudal and rostral. subregions but no significant difference was observed between rostral and caudal dorsomedial subregions. These observations suggest that restraint stress differentially activates NO-producing neurons in distinct DRN subregions. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：174 / 181

页数：8

共 27 条

[1] Anatomic and functional topography of the dorsal raphe nucleus [J].

Abrams, JK ;

Johnson, PL ;

Hollis, JH ;

Lowry, CA .

STRESS: CURRENT NEUROENDOCRINE AND GENETIC APPROACHES, 2004, 1018 :46-57

[2] EXPRESSION OF C-FOS IMMUNOREACTIVITY IN TRANSMITTER-CHARACTERIZED NEURONS AFTER STRESS [J].

CECCATELLI, S ;

VILLAR, MJ ;

GOLDSTEIN, M ;

HOKFELT, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9569-9573

[3] Alterations of nitric oxide synthase expression with aging and hypertension in rats [J].

Chou, TC ;

Yen, MH ;

Li, CY ;

Ding, YA .

HYPERTENSION, 1998, 31 (02) :643-648

[4]

Chung KKK, 2000, NEUROSCIENCE, V95, P453

[5] Differential expression of 5HT-1A, α1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, γ-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus [J].

Day, HEW ;

Greenwood, BN ;

Hammack, SE ;

Watkins, LR ;

Fleshner, M ;

Maier, SF ;

Campeau, S .

JOURNAL OF COMPARATIVE NEUROLOGY, 2004, 474 (03) :364-378

[6] Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups [J].

Dayas, CV ;

Buller, KM ;

Crane, JW ;

Xu, J ;

Day, TA .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (07) :1143-1152

[7] Acute and delayed restraint stress-induced changes in nitric oxide producing neurons in limbic regions [J].

Echeverry, MB ;

Guimaraes, FS ;

Del Bel, EA .

NEUROSCIENCE, 2004, 125 (04) :981-993

[8]

Fite KV, 1999, J COMP NEUROL, V414, P469, DOI 10.1002/(SICI)1096-9861(19991129)414:4<469::AID-CNE4>3.0.CO

[9]

2-P

[10] Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus [J].

Grahn, RE ;

Watkins, LR ;

Maier, SF .

BEHAVIOURAL BRAIN RESEARCH, 2000, 112 (1-2) :33-41

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