A comprehensive review on the biological interest of quinoline and its derivatives

被引：408
作者：
Matada, Basavarajaiah Suliphuldevara [1 ]
Pattanashettar, Raviraj [2 ]
Yernale, Nagesh Gunavanthrao [3 ]
机构：
[1] Vijaya Coll, PG Dept Chem, Bengaluru 560004, Karnataka, India
[2] Salicylates & Chem Pvt Ltd, Hyderabad 500076, Telangana, India
[3] Guru Nanak PG Ctr, Dept Chem, Bidar 585403, Karnataka, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2021年 / 32卷
关键词：
Heterocyclic compounds; Quinolines; Natural sources; Marketed drugs; Approved drugs; Biological Interest; VIVO ANTIMALARIAL ACTIVITY; IN-VITRO ACTIVITY; ANTIMICROBIAL ACTIVITY; 2-SUBSTITUTED QUINOLINES; RECEPTOR ANTAGONISTS; ACQUIRED-RESISTANCE; ANTIFUNGAL ACTIVITY; ANTITUMOR-ACTIVITY; TOPOISOMERASE-II; ADULT PATIENTS;
D O I：
10.1016/j.bmc.2020.115973
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a significant assembly motif for the development of new drug entities. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. Therefore, many scientific communities have developed these compounds as intent structure and evaluated their biological activities. The present, review provides brief natural sources of quinoline and including a new extent of quinoline-based marketed drugs. This review also confers information about the biological activities of quinoline derivatives such as antibacterial, antifungal, antimycobacterial, antiviral, anti-protozoal, antimalarial, anticancer, cardiovascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.
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页数：25
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