A Review of Switching Strategies for Patients with Schizophrenia Comorbid with Metabolic Syndrome or Metabolic Abnormalities

被引：10

作者：

Liao, Xuemei ^{[1
]}

Ye, Hui ^{[2
]}

Si, Tianmei ^{[1
]}

机构：

[1] Peking Univ, Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth,Inst Mental Hlth, Huayuanbeilu 51, Beijing 100191, Peoples R China

[2] Sanofi, Dept Med, Shanghai, Peoples R China

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2021年 / 17卷

基金：

国家重点研发计划;

关键词：

antipsychotics; switch; metabolic syndrome; INDUCED WEIGHT-GAIN; DOUBLE-BLIND; LONG-TERM; ATYPICAL ANTIPSYCHOTICS; BIPOLAR DISORDER; DRUG TREATMENT; ARIPIPRAZOLE; OLANZAPINE; RISK; PREVALENCE;

D O I：

10.2147/NDT.S294521

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Metabolic syndrome (MetS) in patients with schizophrenia occurs 2-3 times more frequently than in the general population. Antipsychotic medication is a primary risk factor for patients with MetS. In particular, the widely used second-generation antipsychotics can affect glucose and lipid metabolism and can induce insulin resistance and other metabolic abnormalities through various receptors. Notably, the metabolic risks of various anti psychotics may differ because of their different pharmacological affinity to MetS-related receptors. Several previous studies have shown that switching from high to low metabolic risk antipsychotics may improve patients' metabolic parameters. The current review aims to discuss the strategies for switching antipsychotic medications and the impact on metabolic abnormalities in patients with schizophrenia.

引用

页码：453 / 469

页数：17

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