COVID-19-neutralizing antibodies predict disease severity and survival

被引：320

作者：

Garcia-Beltran, Wilfredo F. ^{[1
]}

Lam, Evan C. ^{[2
]}

Astudillo, Michael G. ^{[1
]}

Yang, Diane ^{[1
]}

Miller, Tyler E. ^{[1
]}

Feldman, Jared ^{[2
]}

Hauser, Blake M. ^{[2
]}

Caradonna, Timothy M. ^{[2
]}

Clayton, Kiera L. ^{[2
]}

Nitido, Adam D. ^{[2
]}

Murali, Mandakolathur R. ^{[1
,3
]}

Alter, Galit ^{[2
]}

Charles, Richelle C. ^{[4
]}

Dighe, Anand ^{[1
]}

Branda, John A. ^{[1
]}

Lennerz, Jochen K. ^{[1
]}

Lingwood, Daniel ^{[2
]}

Schmidt, Aaron G. ^{[2
]}

Iafrate, A. John ^{[1
]}

Balazs, Alejandro B. ^{[2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[2] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

[3] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02114 USA

来源：

CELL | 2021年 / 184卷 / 02期

关键词：

RESPIRATORY-SYNDROME CORONAVIRUS; SPIKE PROTEIN; NEUTRALIZATION ASSAY; SARS CORONAVIRUS; RETRIEVAL SIGNAL;

D O I：

10.1016/j.cell.2020.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coronavirus disease 2019 (COVID-19) exhibits variable symptom severity ranging from asymptomatic to life-threatening, yet the relationship between severity and the humoral immune response is poorly understood. We examined antibody responses in 113 COVID-19 patients and found that severe cases resulting in intubation or death exhibited increased inflammatory markers, lymphopenia, pro-inflammatory cytokines, and high anti-receptor binding domain (RBD) antibody levels. Although anti-RBD immunoglobulin G (IgG) levels generally correlated with neutralization titer, quantitation of neutralization potency revealed that high potency was a predictor of survival. In addition to neutralization of wild-type SARS-CoV-2, patient sera were also able to neutralize the recently emerged SARS-CoV-2 mutant D614G, suggesting cross-protection from reinfection by either strain. However, SARS-CoV-2 sera generally lacked cross-neutralization to a highly homologous pre-emergent bat coronavirus, WIV1-CoV, which has not yet crossed the species barrier. These results highlight the importance of neutralizing humoral immunity on disease progression and the need to develop broadly protective interventions to prevent future coronavirus pandemics.

引用

页码：476 / +

页数：24

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