The History of Antibiotic Treatment of Osteomyelitis

被引：50

作者：

Cortes-Penfield, Nicolas W. ^{[1
]}

Kulkarni, Prathit A. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Dept Med, Infect Dis Sect, One Baylor Plaza,MS 285,Room 612E, Houston, TX 77030 USA

[2] Michael E DeBakey VA Med Ctr, Med Care Line, Houston, TX USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2019年 / 6卷 / 05期

基金：

美国国家卫生研究院;

关键词：

antibiotic; antimicrobial; bone and joint infection; bone infection; history; oral antibiotics; osteomyelitis; ORAL ANTIMICROBIAL THERAPY; STAPHYLOCOCCUS-AUREUS; VERTEBRAL OSTEOMYELITIS; INTRAVENOUS THERAPY; JOINT INFECTIONS; CLINICAL-TRIAL; CIPROFLOXACIN; CHILDREN; EPIDEMIOLOGY; CLOXACILLIN;

D O I：

10.1093/ofid/ofz181

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibiotic treatment of osteomyelitis has evolved substantially over the past 80 years. Traditional teachings (eg, that antimicrobials must be given parenterally, selected based upon ratios of achieved bone vs serum drug levels, and continued for 4-6 weeks) are supported by limited data. New studies are challenging this dogma, however. In this review, we seek to contextualize the discussion by providing a narrative, chronologic review of osteomyelitis treatment spanning the pre-antibiotic era through the present day and by describing the quality of evidence supporting each component of traditional osteomyelitis therapy.

引用

页数：7

共 70 条

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