Synthesis of cell-wall analogues of vancomycin-resistant enterococci using solid phase peptide synthesis

被引:6
|
作者
Cho, YR [1 ]
Entress, RMH [1 ]
Williams, DH [1 ]
机构
[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CTR MOL RECOGNIT,CAMBRIDGE CB2 1EW,ENGLAND
关键词
D O I
10.1016/S0040-4039(97)01110-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A convenient method for the direct coupling of lithium D-lactate to 2-chlorotrityl chloride resin enabled the rapid and efficient solid phase synthesis of bacterial cell-wall precursor analogues (depsipeptides) found in vancomycin-resistant enterococci (VRE). (C) 1997 Elsevier Science Ltd.
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页码:5229 / 5232
页数:4
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