Selective crystallization of vitamin D3 for the preparation of novel conformational polymorphs with distinctive chemical stability

被引：12

作者：

Wang, Jian-Rong ^{[1
]}

Zhu, Bingqing ^{[1
]}

Yu, Qihui ^{[1
]}

Mei, Xuefeng ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China

来源：

CRYSTENGCOMM | 2016年 / 18卷 / 07期

基金：

中国国家自然科学基金;

关键词：

SOLID-STATE NMR; 1-ALPHA; 25-DIHYDROXYVITAMIN-D3; COCRYSTAL; FORMS;

D O I：

10.1039/c5ce02431e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new conformational polymorph of VD3 containing a pure a conformer was prepared and fully characterized. Chemical stability and hygroscopicity are compared with the marketed solid-state form (form A, two conformers alpha/beta, 1 : 1). The results indicate that crystallization of VD3 needs to be controlled to avoid the unstable polymorph.

引用

页码：1101 / 1104

页数：4

共 26 条

[1] Ostwald's rule and enantiotropy: polymorph appearance in the crystallisation of p-aminobenzoic acid
Black, James F. B.
Davey, Roger J.
Gowers, Richard J.
Yeoh, Alvin
[J]. CRYSTENGCOMM, 2015, 17 (28): : 5139 - 5142
[2] POLYMORPHISM OF PHARMACEUTICALS AND OTHER MOLECULAR-CRYSTALS .1. THEORY OF THERMODYNAMIC RULES
BURGER, A
RAMBERGER, R
[J]. MIKROCHIMICA ACTA, 1979, 2 (3-4) : 259 - 271
[3] Conformational Polymorphism
Cruz-Cabeza, Aurora J.
Bernstein, Joel
[J]. CHEMICAL REVIEWS, 2014, 114 (04) : 2170 - 2191
[4] PHOTOCHEMISTRY OF CONJUGATED TRIENES - VITAMIN-D REVISITED
JACOBS, HJC
[J]. PURE AND APPLIED CHEMISTRY, 1995, 67 (01) : 63 - 70
[5] A new conformational polymorph of N-acetyl-L-cysteine. The role of S-H•••O and C-H•••O interactions
Kumar, S. Sudalai
Nangia, Ashwini
[J]. CRYSTENGCOMM, 2013, 15 (33): : 6498 - 6505
[6] Labler L., 1996, ULLMANNS ENCY IND CH
[7] Structure determination of the theophylline-nicotinamide cocrystal: a combined powder XRD, 1D solid-state NMR, and theoretical calculation study
Li, Ping
Chu, Yueying
Wang, Lin
Wenslow, Robert M., Jr.
Yu, Kaichao
Zhang, Hailu
Deng, Zongwu
[J]. CRYSTENGCOMM, 2014, 16 (15): : 3141 - 3147
[8] Polymorphism in anti-hyperammonemic agent N-carbamoyl-L-glutamic acid
Maddileti, D.
Nangia, Ashwini
[J]. CRYSTENGCOMM, 2015, 17 (28): : 5252 - 5265
[9] A 13C solid-state NMR analysis of vitamin D compounds
Mousavi, Mansoureh
Yu, Steve S. -F.
Tzou, Der-Lii M.
[J]. SOLID STATE NUCLEAR MAGNETIC RESONANCE, 2009, 36 (01) : 24 - 31
[10] Polymorphism
Nangia, Ashwini
Row, T. N. Guru
[J]. CRYSTENGCOMM, 2015, 17 (28): : 5128 - 5128

← 1 2 3 →