Recombinant factor VIIA, its clinical properties, and the tissue factor pathway of coagulation

被引：1
作者：
Bosinski, Timothy J.
El Solh, Ali A.
机构：
[1] Novo Nordisk AS, Med Affairs, Princeton, NJ USA
[2] SUNY Buffalo, Sch Med & Biomed Sci, Dept Med, Div Pulm Crit Care & Sleep Med, Buffalo, NY 14260 USA
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 10期
关键词：
recombinant factor VIIa; tissue factor; hemostasis; coagulation;
D O I：
10.2174/138955706778560201
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Recombinant factor VIIa (rFVIIa) is a synthetic coagulation protease that is structurally similar to human-derived plasma FVIIa. Pharmacologic doses of rFVIIa have been shown to enhance thrombin generation and assist in forming stable fibrin plugs at the site of injury. Recombinant factor VIIa appears to emerge as a valuable treatment alternative for the treatment of bleeding episodes and for achieving hemostasis post surgery in those with bleeding disorders.
引用
收藏
页码：1111 / 1117
页数：7
相关论文
共 67 条
  • [1] Does recombinant factor Vlla, apart from overall hemostasis, regulate TAFI dependent fibrinolysis?: In vitro analysis using overall hemostasis potential (OHP) assay
    Antovic, JP
    Antovic, A
    [J]. THROMBOSIS AND HAEMOSTASIS, 2003, 90 (04) : 620 - 627
  • [2] Antibodies to factor VIIa in patients with haemophilia and high-responding inhibitors
    Astermark, J
    Ekman, M
    Berntorp, E
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2002, 119 (02) : 342 - 347
  • [3] BAJAJ SP, 1981, J BIOL CHEM, V256, P253
  • [4] ISOLATION AND EXPRESSION OF CDNAS ENCODING HUMAN FACTOR-VII
    BERKNER, K
    BUSBY, S
    DAVIE, E
    HART, C
    INSLEY, M
    KISIEL, W
    KUMAR, A
    MURRAY, M
    OHARA, P
    WOODBURY, R
    HAGEN, F
    [J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1986, 51 : 531 - 541
  • [5] Recombinant factor VIIa corrects prothrombin time in cirrhotic patients: A preliminary study
    Bernstein, DE
    Jeffers, L
    Erhardtsen, E
    Reddy, KR
    Glazer, S
    Squiban, P
    Bech, R
    Hedner, U
    Schiff, ER
    [J]. GASTROENTEROLOGY, 1997, 113 (06) : 1930 - 1937
  • [6] Bjoern S, 1986, RES DISCL, V269, P564
  • [7] Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: Two parallel randomized, placebo-controlled, double-blind clinical trials
    Boffard, KD
    Riou, B
    Warren, B
    Choong, PIT
    Rizoli, S
    Rossaint, R
    Axelsen, M
    Kluger, Y
    [J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2005, 59 (01): : 8 - 16
  • [8] BROZE GJ, 1980, J BIOL CHEM, V255, P1242
  • [9] 'Last-ditch' use of recombinant factor VIIa in patients with massive haemorrhage is ineffective
    Clark, AD
    Gordon, WC
    Walker, ID
    Tait, RC
    [J]. VOX SANGUINIS, 2004, 86 (02) : 120 - 124
  • [10] WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING
    DAVIE, EW
    RATNOFF, OD
    [J]. SCIENCE, 1964, 145 (363) : 1310 - &
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