BP1, a potential biomarker for breast cancer prognosis

被引：13

作者：

Lou, Yaoxian ^{[1
]}

Fallah, Yassi ^{[2
]}

Yamane, Kellie ^{[3
]}

Berg, Patricia E. ^{[1
]}

机构：

[1] George Washington Univ, Dept Biochem & Mol Med, Washington, DC 20037 USA

[2] Georgetown Univ, Dept Oncol, Lombardi Comprehens Canc Ctr, Med Ctr, Washington, DC 20057 USA

[3] NantOmics, Diagnost Ctr Montgomery Cty, Rockville, MD 20850 USA

来源：

BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 05期

关键词：

biomarker; BP1; target; breast cancer; distal; less family; DLX4; estrogen receptor; homeobox genes; isoform; oncogene; HOMEOBOX GENE; MESSENGER-RNA; ANTENNAPEDIA HOMEODOMAIN; TAMOXIFEN RESISTANCE; EXPRESSION LEVEL; PROTEIN; DLX4; HOMEOPROTEIN; HOXB7; BETA;

D O I：

10.2217/bmm-2017-0212

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Homeobox genes are critical in tumor development. An isoform protein of DLX4 called BP1 is expressed in 80% of invasive ductal breast carcinomas. BP1 overexpression is implicated in an aggressive phenotype and poor prognosis. BP1 upregulation is associated with estrogen receptor negativity so those tumors do not respond to antiestrogens. Breast cancer is the second leading cause of death in women. BP1 could serve as both a novel prognostic biomarker for breast cancer and a therapeutic target. In this review, we address the role of BP1 protein in tumorigenesis of breast cancer and four other malignancies. A number of functions of BP1 in cancer are also discussed.

引用

页码：535 / 545

页数：11

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