In vitro photodynamic inactivation of Sporothrix schenckii complex species

被引：19
作者：
Nunes Mario, Debora Alves [1 ]
Denardi, Laura Bedin [1 ]
Brayer Pereira, Daniela Isabel [2 ]
Santurio, Janio Morais [1 ]
Alves, Sydney Hartz [1 ]
机构：
[1] Univ Fed Santa Maria, Dept Microbiol & Parasitol, BR-97119900 Santa Maria, RS, Brazil
[2] Univ Fed Pelotas, Dept Microbiol & Parasitol, Pelotas, RS, Brazil
来源：
MEDICAL MYCOLOGY | 2014年 / 52卷 / 07期
关键词：
sporotrichosis; mycosis; PDT; laser; methylene blue; ANTIFUNGAL SUSCEPTIBILITIES; METHYLENE-BLUE; CANDIDA-ALBICANS; THERAPY; PHOTOSENSITIZERS; RESISTANT;
D O I：
10.1093/mmy/myu041
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Photodynamic therapy has been applied successfully against cutaneous and subcutaneous mycoses. We applied methylene blue as a photosensitizing agent and light emitting diode (InGaAlP) against Sporothrix schenckii complex species in an in vitro assay. The viability of the conidia was determined by counting colony-forming units. Methylene blue in conjunction with laser irradiation was able to inhibit the growth of all tested samples. The in vitro inhibition of Sporothrix spp. isolates by laser light deserves in vivo experimental and clinical studies since it may be a promising treatment for cutaneous and subcutaneous sporotrichosis.
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收藏
页码：770 / 773
页数：4
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