Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines

被引：1

作者：

Sanchez de Prada, Laura ^{[1
]}

Sanz Munoz, Ivan ^{[2
]}

Castrodeza Sanz, Javier ^{[1
]}

Ortiz de Lejarazu Leonardo, Raul ^{[2
]}

Eiros Bouza, Jose Maria ^{[2
,3
]}

机构：

[1] Univ Valladolid, Hosp Clin, Valladolid 47003, Spain

[2] Ctr Nacl Gripe Valladolid, Valladolid 47009, Spain

[3] Hosp Univ Rio Hortega Valladolid, Valladolid 47012, Spain

来源：

VACCINES | 2020年 / 8卷 / 04期

关键词：

influenza A; Vaccines; adjuvanted Vaccines; SEASONAL INFLUENZA; INFECTION; VACCINATION; MORTALITY;

D O I：

10.3390/vaccines8040704

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: vaccination is the best approach to prevent influenza infections so far. Serological studies on the effect of different vaccine types are important to address vaccination campaigns and protect our population. In our study, we compared the serological response against influenza A subtypes using the non-adjuvanted influenza vaccine (NAIV) in adults and the elderly and the adjuvanted influenza vaccine (AIV) in the elderly. Methods: We performed a retrospective analysis by hemagglutination inhibition assay (HI) of serum samples right before and 28 days after seasonal influenza vaccination during the 1996-2017 seasons. Conclusions: The AIV presents better performance against the A(H3N2) subtype in the elderly whereas the NAIV induces a better response against A(H1N1)pdm09 in the same group.

引用

页码：1 / 11

页数：11

共 30 条

[1]

[Anonymous], 1997, NOT GUID HARM REQ IN

[2] Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza [J].

Arriola, Carmen ;

Garg, Shikha ;

Anderson, Evan J. ;

Ryan, Patrician A. ;

George, Andrea ;

Zansky, Shelley M. ;

Bennett, Nancy ;

Reingold, Arthur ;

Bargsten, Marisa ;

Miller, Lisa ;

Yousey-Hindes, Kimberly ;

Tatham, Lilith ;

Bohm, Susan R. ;

Lynfield, Ruth ;

Thomas, Ann ;

Lindegren, Mary Lou ;

Schaffner, William ;

Fry, Alicia M. ;

Chaves, Sandra S. .

CLINICAL INFECTIOUS DISEASES, 2017, 65 (08) :1289-1297

[3]

De Lejarazu Leonardo R.O., 2019, VIRUS GRIPE PANDEMIA

[4] Back to the Future for Influenza PreimmunityLooking Back at Influenza Virus History to Infer the Outcome of Future Infections [J].

Francis, Magen Ellen ;

King, Morgan Leslie ;

Kelvin, Alyson Ann .

VIRUSES-BASEL, 2019, 11 (02)

[5]

Francis T, 1960, PROC AM PHILOS SOC, V104, P572

[6] Increased immunogenicity of the MF59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects [J].

Gasparini, R ;

Pozzi, T ;

Montomoli, E ;

Fragapane, E ;

Senatore, F ;

Minutello, M ;

Podda, A .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2001, 17 (02) :135-140

[7] Mortality Attributable to Influenza in England and Wales Prior to, during and after the 2009 Pandemic [J].

Green, Helen K. ;

Andrews, Nick ;

Fleming, Douglas ;

Zambon, Maria ;

Pebody, Richard .

PLOS ONE, 2013, 8 (12)

[8] Estimates of global seasonal influenza-associated respiratory mortality: a modelling study [J].

Iuliano, A. Danielle ;

Roguski, Katherine M. ;

Chang, Howard H. ;

Muscatello, David J. ;

Palekar, Rakhee ;

Tempia, Stefano ;

Cohen, Cheryl ;

Gran, Jon Michael ;

Schanzer, Dena ;

Cowling, Benjamin J. ;

Wu, Peng ;

Kyncl, Jan ;

Ang, Li Wei ;

Park, Minah ;

Redlberger-Fritz, Monika ;

Yu, Hongjie ;

Espenhain, Laura ;

Krishnan, Anand ;

Emukule, Gideon ;

van Asten, Liselotte ;

da Silva, Susana Pereira ;

Aungkulanon, Suchunya ;

Buchholz, Udo ;

Widdowson, Marc-Alain ;

Bresee, Joseph S. ;

Azziz-Baumgartner, Eduardo ;

Cheng, Po-Yung ;

Dawood, Fatimah ;

Foppa, Ivo ;

Olsen, Sonja ;

Haber, Michael ;

Jeffers, Caprichia ;

MacIntyre, C. Raina ;

Newall, Anthony T. ;

Wood, James G. ;

Kundi, Michael ;

PopowKraupp, Therese ;

Ahmed, Makhdum ;

Rahman, Mahmudur ;

Marinho, Fatima ;

Sotomayor Proschle, C. Viviana ;

Vergara Mallegas, Natalia ;

Feng, Luzhao ;

Sa, Li ;

Barbosa-Ramirez, Juliana ;

Malo Sanchez, Diana ;

Abarca Gomez, Leandra ;

Badilla Vargas, Xiomara ;

Acosta Herrera, Betsy ;

Josefa Llanes, Maria .

LANCET, 2018, 391 (10127) :1285-1300

[9] CHARACTERIZATION OF INFLUENZA ANTIBODIES BY SERUM ABSORPTION [J].

JENSEN, KE ;

DAVENPORT, FM ;

HENNESSY, AV ;

FRANCIS, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1956, 104 (02) :199-209

[10] Imprinting, immunodominance, and other impediments to generating broad influenza immunity [J].

Knight, Matthew ;

Changrob, Siriruk ;

Li, Lei ;

Wilson, Patrick C. .

IMMUNOLOGICAL REVIEWS, 2020, 296 (01) :191-204

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