Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines

被引：1
作者：
Sanchez de Prada, Laura [1 ]
Sanz Munoz, Ivan [2 ]
Castrodeza Sanz, Javier [1 ]
Ortiz de Lejarazu Leonardo, Raul [2 ]
Eiros Bouza, Jose Maria [2 ,3 ]
机构：
[1] Univ Valladolid, Hosp Clin, Valladolid 47003, Spain
[2] Ctr Nacl Gripe Valladolid, Valladolid 47009, Spain
[3] Hosp Univ Rio Hortega Valladolid, Valladolid 47012, Spain
来源：
VACCINES | 2020年 / 8卷 / 04期
关键词：
influenza A; Vaccines; adjuvanted Vaccines; SEASONAL INFLUENZA; INFECTION; VACCINATION; MORTALITY;
D O I：
10.3390/vaccines8040704
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: vaccination is the best approach to prevent influenza infections so far. Serological studies on the effect of different vaccine types are important to address vaccination campaigns and protect our population. In our study, we compared the serological response against influenza A subtypes using the non-adjuvanted influenza vaccine (NAIV) in adults and the elderly and the adjuvanted influenza vaccine (AIV) in the elderly. Methods: We performed a retrospective analysis by hemagglutination inhibition assay (HI) of serum samples right before and 28 days after seasonal influenza vaccination during the 1996-2017 seasons. Conclusions: The AIV presents better performance against the A(H3N2) subtype in the elderly whereas the NAIV induces a better response against A(H1N1)pdm09 in the same group.
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页码：1 / 11
页数：11
相关论文
共 30 条
  • [1] [Anonymous], 1997, NOT GUID HARM REQ IN
  • [2] Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza
    Arriola, Carmen
    Garg, Shikha
    Anderson, Evan J.
    Ryan, Patrician A.
    George, Andrea
    Zansky, Shelley M.
    Bennett, Nancy
    Reingold, Arthur
    Bargsten, Marisa
    Miller, Lisa
    Yousey-Hindes, Kimberly
    Tatham, Lilith
    Bohm, Susan R.
    Lynfield, Ruth
    Thomas, Ann
    Lindegren, Mary Lou
    Schaffner, William
    Fry, Alicia M.
    Chaves, Sandra S.
    [J]. CLINICAL INFECTIOUS DISEASES, 2017, 65 (08) : 1289 - 1297
  • [3] De Lejarazu Leonardo R.O., 2019, VIRUS GRIPE PANDEMIA
  • [4] Back to the Future for Influenza PreimmunityLooking Back at Influenza Virus History to Infer the Outcome of Future Infections
    Francis, Magen Ellen
    King, Morgan Leslie
    Kelvin, Alyson Ann
    [J]. VIRUSES-BASEL, 2019, 11 (02):
  • [5] Francis T., 1960, P AM PHILOS SOC, V104, P572
  • [6] Increased immunogenicity of the MF59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects
    Gasparini, R
    Pozzi, T
    Montomoli, E
    Fragapane, E
    Senatore, F
    Minutello, M
    Podda, A
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2001, 17 (02) : 135 - 140
  • [7] Mortality Attributable to Influenza in England and Wales Prior to, during and after the 2009 Pandemic
    Green, Helen K.
    Andrews, Nick
    Fleming, Douglas
    Zambon, Maria
    Pebody, Richard
    [J]. PLOS ONE, 2013, 8 (12):
  • [8] Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
    Iuliano, A. Danielle
    Roguski, Katherine M.
    Chang, Howard H.
    Muscatello, David J.
    Palekar, Rakhee
    Tempia, Stefano
    Cohen, Cheryl
    Gran, Jon Michael
    Schanzer, Dena
    Cowling, Benjamin J.
    Wu, Peng
    Kyncl, Jan
    Ang, Li Wei
    Park, Minah
    Redlberger-Fritz, Monika
    Yu, Hongjie
    Espenhain, Laura
    Krishnan, Anand
    Emukule, Gideon
    van Asten, Liselotte
    da Silva, Susana Pereira
    Aungkulanon, Suchunya
    Buchholz, Udo
    Widdowson, Marc-Alain
    Bresee, Joseph S.
    Azziz-Baumgartner, Eduardo
    Cheng, Po-Yung
    Dawood, Fatimah
    Foppa, Ivo
    Olsen, Sonja
    Haber, Michael
    Jeffers, Caprichia
    MacIntyre, C. Raina
    Newall, Anthony T.
    Wood, James G.
    Kundi, Michael
    PopowKraupp, Therese
    Ahmed, Makhdum
    Rahman, Mahmudur
    Marinho, Fatima
    Sotomayor Proschle, C. Viviana
    Vergara Mallegas, Natalia
    Feng, Luzhao
    Sa, Li
    Barbosa-Ramirez, Juliana
    Malo Sanchez, Diana
    Abarca Gomez, Leandra
    Badilla Vargas, Xiomara
    Acosta Herrera, Betsy
    Josefa Llanes, Maria
    [J]. LANCET, 2018, 391 (10127) : 1285 - 1300
  • [9] CHARACTERIZATION OF INFLUENZA ANTIBODIES BY SERUM ABSORPTION
    JENSEN, KE
    DAVENPORT, FM
    HENNESSY, AV
    FRANCIS, T
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1956, 104 (02) : 199 - 209
  • [10] Imprinting, immunodominance, and other impediments to generating broad influenza immunity
    Knight, Matthew
    Changrob, Siriruk
    Li, Lei
    Wilson, Patrick C.
    [J]. IMMUNOLOGICAL REVIEWS, 2020, 296 (01) : 191 - 204
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