Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis

被引：0

作者：

de Castro, Marcio Botelho ^{[1
]}

Juan Szabo, Matias Pablo ^{[2
]}

Thomaz de Aquino, Lucia Padilha Cury ^{[3
]}

Dagnoni, Ana Silvia ^{[4
]}

Alessi, Antonio Carlos ^{[5
]}

Costa, Mirela Tinucci ^{[6
]}

Higa Nakaghi, Andrea Cristina ^{[7
]}

De Santi, Mariele ^{[5
]}

Calchi, Ana Claudia ^{[5
]}

Andre, Marcos Rogerio ^{[5
]}

Machado, Rosangela Zacarias ^{[5
]}

机构：

[1] Univ Brasilia UnB, Lab Patol Vet, Brasilia, DF, Brazil

[2] Univ Fed Uberlandia UFU, Fac Med Vet, Uberlandia, MG, Brazil

[3] Univ Estado Santa Catarina UDESC, Dept Med Vet, Florianopolis, SC, Brazil

[4] Clin Vet Vets Pets, Bady Bassitt, SP, Brazil

[5] Univ Estadual Paulista UNESP, Fac Ciencias Agr & Vet FCAV, Dept Patol Reprod & Saude Unica, Jaboticabal, SP, Brazil

[6] Univ Estadual Paulista UNESP, Fac Ciencias Agr & Vet FCAV, Dept Clin & Cirurgia Vet, Jaboticabal, SP, Brazil

[7] Univ Sorocaba UNISO, Sorocaba, SP, Brazil

来源：

REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA | 2022年 / 31卷 / 02期

关键词：

Monocytic ehrlichiosis; canine; tick-borne disease; infection; immunity; SHOCK-LIKE-SYNDROME; MONOCYTIC EHRLICHIOSIS; CHAFFEENSIS INFECTION; SEQUENTIAL REACTION; DOWN-REGULATION; ANIMAL-MODEL; TNF-ALPHA; PATHOGENESIS; CELLS; RESPONSES;

D O I：

10.1590/S1984-29612022020

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Canine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Immunophenotyping of cells in lymph nodes, spleen and injured tissues highlighted differences in lymphocyte subsets, local expression of immunoglobulin subclasses and MHCII molecules between infected and control dogs. These findings suggest that the immunophenotypic and immunopathological changes in dogs with acute experimental CME are related to Th1 bias and compartmentalized immune response.

引用

页数：13

共 48 条

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