Oral hygiene and the overall survival of head and neck cancer patients

被引：30

作者：

Chang, Chan-Chi ^{[1
,2
]}

Lee, Wei-Ting ^{[1
,2
]}

Hsiao, Jenn-Ren ^{[1
,2
]}

Ou, Chun-Yen ^{[1
]}

Huang, Cheng-Chih ^{[1
]}

Tsai, Sen-Tien ^{[1
]}

Chen, Ken-Chung ^{[3
]}

Huang, Jehn-Shyun ^{[3
]}

Wong, Tung-Yiu ^{[3
]}

Lai, Yu-Hsuan ^{[2
,4
]}

Wu, Yuan-Hua ^{[4
]}

Hsueh, Wei-Ting ^{[4
]}

Wu, Shang-Yin ^{[2
,5
]}

Yen, Chia-Jul ^{[2
,5
]}

Chang, Jong-Yang ^{[5
,6
]}

Lin, Chen-Lin ^{[7
]}

Weng, Ya-Ling ^{[6
]}

Yang, Han-Chien ^{[6
]}

Chen, Yu-Shan ^{[1
]}

Chang, Jeffrey S. ^{[6
]}

机构：

[1] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Otolaryngol, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan, Taiwan

[3] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Stomatol, Tainan, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Radiat Oncol, Tainan, Taiwan

[5] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Div Hematol Oncol,Dept Internal Med, Tainan, Taiwan

[6] Natl Hlth Res Inst, Natl Inst Canc Res, Tainan, Taiwan

[7] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Nursing, Tainan, Taiwan

来源：

CANCER MEDICINE | 2019年 / 8卷 / 04期

关键词：

epidemiology and prevention; gene-environmental interaction; head and neck cancer; survival; INDEPENDENT PROGNOSTIC-FACTOR; SQUAMOUS-CELL CARCINOMA; ASSOCIATION; HEALTH; RISK; EPIDEMIOLOGY; POLYMORPHISM; ALCOHOL; SMOKING;

D O I：

10.1002/cam4.2059

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Poor oral hygiene is an established risk factor of head and neck cancer (HNC); however, its role in the survival of HNC patients is unclear. This study evaluated the association between oral hygiene habits, including regular dental visits, frequency of tooth brushing, and use of dental floss, and the overall survival (OS) of HNC patients using interview data collected from 740 HNC patients. In addition, the interactions between oral hygiene and the polymorphisms of TLR2 and TLR4 on the OS of HNC patients were assessed. The analysis indicated that poor oral hygiene was significantly associated with poorer OS of HNC patients (hazard ratio (HR)=1.38, 95% confidence interval (CI): 1.03-1.86). This association was modified by a single nucleotide polymorphism, rs11536889, of TLR4. A significant association between poor oral hygiene and worse survival of HNC was observed among those with the CG or CC genotype (HR=2.32, 95% CI: 1.41-3.82) but not among those with the GG genotype (HR=0.95, 95% CI: 0.65-1.40). Our results suggested that poor oral hygiene is not only a risk factor but may also be a prognostic factor of HNC. Poor oral hygiene was associated with a worse survival of head and neck cancer. TLR4 affected the survival of head and neck cancer due to poor oral hygiene. Poor oral hygiene is both a risk and a prognostic factor of head and neck cancer

引用

页码：1854 / 1864

页数：11

共 27 条

[1] Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: The ARCAGE study [J].

Ahrens, Wolfgang ;

Pohlabeln, Hermann ;

Foraita, Ronja ;

Nelis, Mari ;

Lagiou, Pagona ;

Lagiou, Areti ;

Bouchardy, Christine ;

Slamova, Alena ;

Schejbalova, Miriam ;

Merletti, Franco ;

Richiardi, Lorenzo ;

Kjaerheim, Kristina ;

Agudo, Antonio ;

Castellsague, Xavier ;

Macfarlane, Tatiana V. ;

Macfarlane, Gary J. ;

Lee, Yuan-Chin Amy ;

Talamini, Renato ;

Barzan, Luigi ;

Canova, Cristina ;

Simonato, Lorenzo ;

Thomson, Peter ;

McKinney, Patricia A. ;

McMahon, Alex D. ;

Znaor, Ariana ;

Healy, Claire M. ;

McCartan, Bernad E. ;

Metspalu, Andres ;

Marron, Manuela ;

Hashibe, Mia ;

Conway, David I. ;

Brennan, Paul .

ORAL ONCOLOGY, 2014, 50 (06) :616-625

[2]

[Anonymous], 2008, WORLD CANC REPORT

[3] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[4] HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients [J].

Castellsague, Xavier ;

Alemany, Laia ;

Quer, Miquel ;

Halec, Gordana ;

Quiros, Beatriz ;

Tous, Sara ;

Clavero, Omar ;

Alos, Llucia ;

Biegner, Thorsten ;

Szafarowski, Tomasz ;

Alejo, Maria ;

Holzinger, Dana ;

Cadena, Enrique ;

Claros, Edith ;

Hall, Gillian ;

Laco, Jan ;

Poljak, Mario ;

Benevolo, Maria ;

Kasamatsu, Elena ;

Mehanna, Hisham ;

Ndiaye, Cathy ;

Guimera, Nuria ;

Lloveras, Belen ;

Leon, Xavier ;

Ruiz-Cabezas, Juan C. ;

Alvarado-Cabrero, Isabel ;

Kang, Chang-Suk ;

Oh, Jin-Kyoung ;

Garcia-Rojo, Marcial ;

Iljazovic, Ermina ;

Ajayi, Oluseyi F. ;

Duarte, Flora ;

Nessa, Ashrafun ;

Tinoco, Leopoldo ;

Duran-Padilla, Marco A. ;

Pirog, Edyta C. ;

Viarheichyk, Halina ;

Morales, Hesler ;

Costes, Valerie ;

Felix, Ana ;

Germar, Maria Julieta V. ;

Mena, Marisa ;

Ruacan, Arzu ;

Jain, Asha ;

Mehrotra, Ravi ;

Goodman, Marc T. ;

Lombardi, Luis Estuardo ;

Ferrera, Annabelle ;

Malami, Sani ;

Albanesi, Estela I. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2016, 108 (06)

[5] Investigating the association between oral hygiene and head and neck cancer [J].

Chang, Jeffrey S. ;

Lo, Hung-I ;

Wong, Tung-Yiu ;

Huang, Cheng-Chih ;

Lee, Wei-Ting ;

Tsai, Sen-Tien ;

Chen, Ken-Chung ;

Yen, Chia-Jui ;

Wu, Yuan-Hua ;

Hsueh, Wei-Ting ;

Yang, Ming-Wei ;

Wu, Shang-Yin ;

Chang, Kwang-Yu ;

Chang, Jang-Yang ;

Ou, Chun-Yen ;

Wang, Yi-Hui ;

Weng, Ya-Ling ;

Yang, Han-Chien ;

Wang, Fang-Ting ;

Lin, Chen-Lin ;

Huang, Jehn-Shyun ;

Hsiao, Jenn-Ren .

ORAL ONCOLOGY, 2013, 49 (10) :1010-1017

[6]

Dalla Torre D, 2018, CLIN ORAL INVESTIG

[7] Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study [J].

Divaris, Kimon ;

Olshan, Andrew F. ;

Smith, Joanna ;

Bell, Mary E. ;

Weissler, Mark C. ;

Funkhouser, William K. ;

Bradshaw, Patrick T. .

CANCER CAUSES & CONTROL, 2010, 21 (04) :567-575

[8] ALCOHOL, SMOKING, SOCIAL AND OCCUPATIONAL FACTORS IN THE ETIOLOGY OF CANCER OF THE ORAL CAVITY, PHARYNX AND LARYNX [J].

ELWOOD, JM ;

PEARSON, JCG ;

SKIPPEN, DH ;

JACKSON, SM .

INTERNATIONAL JOURNAL OF CANCER, 1984, 34 (05) :603-612

[9] Poor oral health affects survival in head and neck cancer [J].

Farquhar, Douglas R. ;

Divaris, Kimon ;

Mazul, Angela L. ;

Weissler, Mark C. ;

Zevallos, Jose P. ;

Olshan, Andrew F. .

ORAL ONCOLOGY, 2017, 73 :111-117

[10]

Ferlay J., 2013, GLOBOCAN 2012 CANC I

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